(n.) Inconvenience; trouble; annoyance; disadvantage; encumbrance.

abash abrade abuse a privilege addle addle the wits ado afflict aggravate aggravation agitate agitation ail annoy annoyance anxiety awkwardness bad news badger baffle bafflement bait ball up be at be the matter becloud bedazzle bedevil bedevilment befuddle befuddlement beset besetment bewilder bewilderment bore botheration bothersomeness brawl bristle broil brouhaha brown off bug bullyrag burden burdening burn up burst bustle can of worms chafe chaos charging chivy cloud clumsiness commotion complicate matters concern confoundment confuse confusion crashing bore daze dazzle demand devil devilment difficulty dilemma disaccommodate disadvantage discombobulate discombobulation discomfit discomfiture discomfort discommode discommodity discompose discomposure disconcert disconcertedness disconcertion disconcertment dismay disoblige disorder disorganization disorganize disorient disorientation disquiet distemper distress disturb disturbance dither dog dogging donnybrook donnybrook fair downer drag dustup effort embarrass embarrassment embroilment encroach upon enigma entangle evil exaction exasperate exasperation exercise fash feery-fary ferment fidgetiness fit fix flap flummox flurry fluster flusteration flustration flutter flutteriness fog foofaraw fracas frazzle free-for-all freighting frenzy fret fuddle fuddlement fuss fuss at fussiness get give concern great ado gripe harass harassment harry harrying hassle haze headache heckle hector helter-skelter hound hounding hubbub hullabaloo impose on impose upon imposing an onus imposition incommode incommodity inconsiderateness inconvenience inconveniency inconvenientness infliction irk irritant irritate irritation jam jumble lather laying on load with care loading loading down maelstrom make free with matter maze melee mess miff mist mix up moider molest molestation muddle muddlement mystery nag needle nettle nonplus nudge nudzh nuisance obtrude upon obtrusiveness overstep pain peck of troubles peeve pell-mell perplex perplexity persecute persecution perturb perturbation pest pester pet pick on pickle pique plague plight pluck the beard pother predicament presume on presume upon presumptuousness problem provoke pucker put out put to inconvenience put to it put to trouble puzzle puzzlement quandary racket raise hell rampage rattle restlessness riddle ride rile riot roil rough-and-tumble