1. (v. t.) To affect with pain or uneasiness, either physical or mental; to trouble; to be the matter with; -- used to express some uneasiness or affection, whose cause is unknown; as, what ails the man? I know not what ails him.

2. (v. i.) To be affected with pain or uneasiness of any sort; to be ill or indisposed or in trouble.

3. (n.) Indisposition or morbid affection.

ache afflict agonize anguish be affected with be the matter beset bite blanch blench bother burn chafe complain of complicate matters concern convulse crucify cut discommode distress disturb excruciate feel ill feel pain feel the pangs fester fret gall give pain gnaw grate grimace grind gripe harass harrow have a misery hurt inconvenience inflame inflict pain irk irritate kill by inches labor under lacerate martyr martyrize nip pain perplex perturb pierce pinch plague pother pound prick prolong the agony put out put to it put to torture puzzle rack rankle rasp rub shoot shrink smart stab sting suffer thrill throb tingle torment torture trouble try tweak twinge twist twitch upset vex wince worry wound wring writhe