1. (n.) Deprivation of advantage; unfavorable or prejudicial quality, condition, circumstance, or the like; that which hinders success, or causes loss or injury.

2. (n.) Loss; detriment; hindrance; prejudice to interest, fame, credit, profit, or other good.

3. (v. t.) To injure the interest of; to be detrimental to.

abuse ado afflict aggrieve annoyance anxiety bar befoul besetment bewitch blight blocking bother burden burthen can of worms cargo charge condemn corrupt cross crucify cumbrance curse damage deadweight defect defile deprave deprivation despoil destroy detriment difficulty disability disaccommodate discommode disoblige disserve disservice distress do a mischief do evil do ill do wrong do wrong by doom drawback embarrassment encumbrance envenom evil fault flaw freight get into trouble great ado hamper handicap harass harm headache hex hindrance hurt impair impairment impediment impedimenta impose upon imposition incommode inconvenience infect injure injury jinx liability load loss loss of ground lumber maltreat matter menace mischief mistreat molest obstacle obstruction onus outrage pack peck of troubles penalty persecute play havoc with play hob with poison pollute prejudice problem put out put to inconvenience put to trouble savage scathe sea of troubles shortcoming step backward taint threaten torment torture trouble violate weakness weight white elephant worry wound wreak havoc on wrong