1. (n.) A fatal epidemic disease; a pestilence; specif., the plague.

2. (n.) Anything which resembles a pest; one who, or that which, is troublesome, noxious, mischievous, or destructive; a nuisance.

affliction aggravation ambulatory plague annoyance annoyer bad news badgerer bane bedevilment besetment black death black plague blast blight bore bother botheration bothersomeness bubonic plague bugbear bully burden buttonholer calamity cancer canker cellulocutaneous plague crashing bore crushing burden curse death defervescing plague destruction devilment difficulty disease dogging downer drag drip dry rot dryasdust dusty epidemic epiphytotic epizootic evil exasperation flat tire frightful bore fungus gadfly glandular plague grievance harasser harassment harm harrier harrying headache heckler hemorrhagic plague hounding humdrum infliction irritant larval plague mildew mold molestation moth moth and rust murrain must nag nemesis nudnik nudzh nuisance open wound pandemia pandemic persecution persecutor pester pesterer pesthole pestilence pill plague plague spot plaguer pneumonic plague premonitory plague problem proser rot running sore rust sadist scourge septicemic plague siderating plague smut tease teaser thorn torment tormentor trial trouble tuberculosis twaddler vexation vexatiousness visitation wet blanket white plague woe worm worriment worry