1. (n.) Punishment suffered or denounced; suffering or evil inflicted as a punishment for crime, or connected with the commission of a crime; penalty.

2. (n.) Any uneasy sensation in animal bodies, from slight uneasiness to extreme distress or torture, proceeding from a derangement of functions, disease, or injury by violence; bodily distress; bodily suffering; an ache; a smart.

3. (n.) Specifically, the throes or travail of childbirth.

4. (n.) Uneasiness of mind; mental distress; disquietude; anxiety; grief; solicitude; anguish.

5. (n.) See Pains, labor, effort.

6. (n.) To inflict suffering upon as a penalty; to punish.

7. (n.) To put to bodily uneasiness or anguish; to afflict with uneasy sensations of any degree of intensity; to torment; to torture; as, his dinner or his wound pained him; his stomach pained him.

8. (n.) To render uneasy in mind; to disquiet; to distress; to grieve; as a child's faults pain his parents.

abscess ache aching afflict affliction aggrieve agonize agony ague ail anemia anguish ankylosis annoyance anoxia apnea asphyxiation assiduousness asthma ataxia atrophy backache barb the dart bite bitterness bleakness bleeding blennorhea blow bore bother bruise burn cachexia cachexy castigation chafe chastening chastisement cheerlessness chill chills colic comfortlessness condign punishment constipation constrain convulse convulsion correction coughing cramp crucify cut cut up cyanosis depress depression deserts despair diarrhea diligence disciplinary measures discipline discomfort discomposure dismalness dismay disquiet distress distressfulness dizziness dolor drag dreariness dropsy dysentery dyspepsia dyspnea edema effort elbow grease emaciation excruciate exertion fainting fatigue ferule fester fever fibrillation flux fret gall give pain gnaw grate grief grieve grievousness grind gripe growth harass harrow headache hemorrhage high blood pressure hurt hurt the feelings hydrops hypertension hypotension icterus indigestion industry inflame inflammation inflict pain infliction injure injury insomnia irk irritate irritation itching jaundice joylessness judgment judicial punishment kill by inches labor labored breathing lacerate lament lamentability lamentation lesion low blood pressure lumbago marasmus martyr martyrize misery mourn mournfulness nasal discharge nasty blow nausea necrosis nemesis nip nuisance ordeal painfulness pains pains and punishments pang paralysis passion pathos pay payment penal retribution penalty penology pest pierce pinch pitiability pitiableness pitifulness poignancy prick prolong the agony pruritus punishment punition put to torture rack rankle rash rasp regrettableness retribution retributive justice rheum rub sadden sadness sclerosis scourge sedulousness seizure sharpness shock skin eruption smarting sneezing sore sore spot soreness sorrow sorrowfulness spasm stab sting stitch strain stress stress of life stroke suffer suffering tabes tachycardia tender spot throes toil torment torture travail trial tribulation trouble try tumor tweak twinge twist twist the knife upset upset stomach vertigo vexation vomiting wasting well-deserved punishment what-for while woe woebegoneness woefulness wound wrench wretchedness wring