1. (n.) The state of being discomposed; disturbance; disorder; agitation; perturbation.

2. (n.) Discordance; disagreement of parts.

abashment agitation angst anguish anxiety baffle bafflement befuddlement bewilderment bluster bobbery boil boiling boredom bother botheration brouhaha bustle chagrin chaos cheerlessness churn cloud commotion confoundment confusion conturbation convulsion daze derangement dilemma disarrangement disarray disarticulation discombobulation discomfiture discomfort disconcert disconcertedness disconcertion disconcertment discontent discountenance disharmony dishevelment disintegration disjunction dislike dislocation disorder disorderliness disorganization disorientation displeasure disproportion disquiet disquietude disruption dissatisfaction distress disturbance dread dullness ebullition embarrassment embroilment emptiness enigma ennui entropy excitement existential woe ferment fermentation fever feverishness fidgets fix flap flatness flummox flurry fluster flutter flutteration fog foment frenzy fuddle fuddlement fume fuss grimness haphazardness haze hubbub hurly-burly incoherence indiscriminateness inharmonious harmony inquietude insanity irregularity jam jitters joylessness jumble jumpiness lack of pleasure maelstrom malaise maze mess misarrangement mist moil mortification most admired disorder muddle muddlement mystery nausea nerviness nervosity nervousness nongratification nonplus nonsatisfaction nonsymmetry nonuniformity painfulness perplexity perturbation pickle plight pother predicament problem promiscuity promiscuousness pucker puzzle puzzlement quandary randomness restlessness riddle roil rout row ruffle savorlessness scrape seethe seething shuffle shuffling spleen staleness stew stir sweat swirl swivet tastelessness tediousness tedium tizzy to-do trepidation trepidity tumult tumultuation turbidity turbulence turmoil twitter unassuredness uncomfortableness unease uneasiness unhappiness unpleasure unrest unsatisfaction unsettlement unsymmetry ununiformity upset vexation of spirit