1. (v. t.) To fatigue; to tire with repeated and exhausting efforts; to cause to endure excessive burdens or anxieties\; -- sometimes followed by out.

2. (n.) Devastation; waste.

3. (n.) Worry; harassment.

abuse afflict aggravate aggrieve ail annoy badger bait be at be the matter beat bedevil befoul beleaguer beset besiege bewitch blight blockade bludgeon bluster bluster out of bother bristle browbeat brown off bug bulldoze bully bullyrag burn out burn up chevy chivy complicate matters concern condemn corrupt cow crucify curse damage debilitate defile demoralize deprave despoil destroy devil disadvantage discommode discompose disserve distemper distress disturb do a mischief do evil do ill do in do up do wrong do wrong by dog doom dragoon encircle encompass enervate envelop envenom exasperate exercise exhaust fag fag out fash fatigue flag foray frazzle fret get get into trouble gnaw gripe harm harry haunt heckle hector hex hound huff hunt hurt impair inconvenience infect injure intimidate invest irk irritate jade jinx knock out knock up lay siege to maltreat maraud menace miff mistreat molest nag needle nettle nudzh oppress outrage overfatigue overstrain overtire overweary pain peeve perplex persecute perturb pester pick at pick on pique plague play havoc with play hob with pluck the beard poison pollute poop poop out pother prejudice prostrate provoke pursue put out put to it puzzle ride rile roil ruffle savage scathe soften up strain stress surround systematically terrorize taint tease terrorize threaten tire tire out tire to death torment torture trouble try try the patience tucker tweak the nose use up vex victimize violate weaken wear wear down wear on wear out weary wilt wind worry wound wreak havoc on wrong