(n.) The act of bothering, or state of being bothered; cause of trouble; perplexity; annoyance; vexation.

agitation annoyance anxiety besetment bother botheration brawl broil brouhaha burst bustle can of worms commotion confusion disadvantage disturbance donnybrook donnybrook fair dustup ebullience ebullition eddy effervescence effort embroilment evil exertion feery-fary ferment fermentation fidgetiness fit flap flurry fluster flutter flutteriness foofaraw fracas free-for-all fume furore fuss fussiness great ado hassle headache helter-skelter hubbub hullabaloo hurly-burly hurry hurry-scurry inconvenience maelstrom matter melee pains peck of troubles pell-mell perturbation pother problem racket rampage restlessness riot rough-and-tumble roughhouse row ruckus ruction ruffle rumpus scramble sea of troubles shindy spasm spurt stew stir sweat swirl swirling to-do trouble tumult turbulence turmoil unquiet uproar vortex whirl whirlpool whirlwind worry yeastiness