1. (v. t.) To strike or cast down; to overthrow.

2. (v. t.) To inflict some great injury or hurt upon, causing continued pain or mental distress; to trouble grievously; to torment.

3. (v. t.) To make low or humble.

4. (p. p. & a.) Afflicted.

abuse affect aggrieve agitate agonize ail anguish annoy befoul bewitch bite blight bother break down bring to tears burden burn chafe condemn convulse corrupt crucify crush curse cut cut up damage debilitate defile deprave derange desolate despoil destroy devitalize disable disadvantage discomfort disorder disquiet disserve distress disturb do a mischief do evil do ill do wrong do wrong by doom draw tears embitter enervate enfeeble envenom excruciate fester fret gall get into trouble give pain gnaw grate grieve grind gripe harass harm harrow harry hex hospitalize hurt impair incapacitate indispose infect inflame inflict pain injure inundate invalid irk irritate jinx kill by inches lacerate lay up load with care maltreat martyr martyrize menace mistreat molest nip oppress outrage overwhelm pain persecute perturb pester pierce pinch plague play havoc with play hob with poison pollute prejudice press prick prolong the agony prostrate put to it put to torture rack rankle rasp reduce rub savage scathe sicken smite sorrow stab sting strike taint threaten torment torture trouble try tweak twist upset vex violate weaken worry wound wreak havoc on wring wrong