Amytal Amytal pill Demerol Dolophine H Luminal Luminal pill M Mickey Finn Nembutal Nembutal pill Schmerz Seconal Seconal pill Slough of Despond Tuinal Tuinal pill adverse circumstances adversity affliction aggravation alcohol amobarbital sodium analgesic annoyance anodyne bad news barb barbiturate barbiturate pill bedevilment black stuff blank despondency blight blue blue angel blue devil blue heaven blue velvet bore bother botheration bothersomeness bummer calmative care chloral hydrate codeine codeine cough syrup crashing bore cross curse death wish dejectedness dejection depressant depression depressor despair despondency despondentness devilment difficulties difficulty discouragement disheartenment dispiritedness dogging dolly down trip downcastness downheartedness drag drooping spirits exasperation goofball harassment hard knocks hard life hard lot hard stuff hardcase hardship harrying headache heartlessness heroin hop hopelessness horse hounding hypnotic irritation junk knockout drops laudanum liquor lotus low spirits lowness lowness of spirit malaise meperidine methadone molestation morphia morphine narcotic nuisance opiate opium oppression pacifier pain killer paregoric pen yan persecution pessimism pest phenobarbital phenobarbital sodium plight predicament pressure problem purple heart quietener rainbow red rigor scag sea of troubles secobarbital sodium sedative self-destructive urge shit sinking heart sleep-inducer sleeper sleeping draught sleeping pill smack sodium thiopental somnifacient soother soothing syrup soporific spiritlessness stress stress of life suicidal despair taedium vitae tar tranquilizer trial tribulation trouble troubles turps vale of tears vexation vexatiousness vicissitude weariness of life white stuff worriment worry yellow yellow jacket