abnormality acute disease adverse circumstances adversity affection aggravation ailment allergic disease allergy anguish annoyance atrophy bacterial disease bane birth defect bitter cup bitter draft bitter draught bitter pill blight bugbear bummer burden burden of care calamity calvary cankerworm of care cardiovascular disease care catastrophe chronic disease circulatory disease complaint complication condition congenital defect cross crown of thorns crucible crushing burden curse death defect deficiency disease deformity degenerative disease destruction difficulties difficulty disability disaster disease disorder distemper distress dole downer encumbrance endemic endemic disease endocrine disease epidemic disease evil functional disease fungus disease gall gall and wormwood gastrointestinal disease genetic disease grief grievance handicap hard knocks hard life hard lot hardcase hardship harm heartache heartbreak hereditary disease iatrogenic disease illness indisposition infectious disease infirmity infliction irritation load malady malaise mischance misery misfortune mishap morbidity morbus muscular disease nemesis neurological disease nutritional disease occupational disease open wound oppression ordeal organic disease pack of troubles pain pandemic disease pathological condition pathology peck of troubles pest pestilence plague plant disease plight predicament pressure protozoan disease psychosomatic disease regret respiratory disease rigor rockiness rue running sore scourge sea of troubles secondary disease seediness sickishness sickness signs sorrow stress stress of life suffering symptomatology symptomology symptoms syndrome the pip thorn torment trial tribulation trouble troubles urogenital disease vale of tears vexation vicissitude virus disease visitation wasting disease waters of bitterness weight woe worm disease wretchedness