1. (v. t.) To call upon divine or supernatural power to send injury upon; to imprecate evil upon; to execrate.

2. (v. t.) To bring great evil upon; to be the cause of serious harm or unhappiness to; to furnish with that which will be a cause of deep trouble; to afflict or injure grievously; to harass or torment.

3. (v. i.) To utter imprecations or curses; to affirm or deny with imprecations; to swear.

4. (n.) An invocation of, or prayer for, harm or injury; malediction.

5. (v. t.) Evil pronounced or invoked upon another, solemnly, or in passion; subjection to, or sentence of, divine condemnation.

6. (n.) The cause of great harm, evil, or misfortune; that which brings evil or severe affliction; torment.

Jonah abuse accurse adverse circumstances adversity afflict affliction aggravation aggrieve anathema anathematize annoyance bad influence bad language bane befoul bewitch bitter cup bitter draft bitter draught bitter pill blaspheme blasphemy blast blight bugbear bummer burden burden of care calamity cankerworm of care cantrip care catamenia catamenial discharge charm commination condemn confound corrupt courses cross crown of thorns crucify crushing burden curse and swear cuss cuss word damage damn damnation damning darn death defile denounce denunciation deprave despoil destroy destruction difficulties difficulty dirty name dirty word disadvantage disease disserve distress do a mischief do evil do ill do wrong do wrong by doom downer dysphemism dysphemize enchantment encumbrance envenom epithet evil evil eye evil genius evil star excommunicate execrate execration exorcism expletive flowers foul invective fulminate against gall gall and wormwood get into trouble glamour grievance handicap harass hard knocks hard life hard lot hardcase hardship harm hex hoodoo hurt ill wind impair imprecate imprecation infect infliction injure irritation jinx load magic spell malediction malevolent influence malocchio maltreat menace menses menstrual discharge menstruation misfortune mistreat molest monthlies naughty word nemesis no-no oath objurgate objurgation obscenity open wound oppression outrage pack of troubles peck of troubles period periods persecute pest pestilence plague play havoc with play hob with plight poison pollute predicament prejudice pressure profanation profane oath profanity rigor running sore sacrilege saddle savage scathe scatologize scourge sea of troubles sorrow spell stress stress of life swear swear at swearword taint talk dirty that time the curse thorn threaten throw a whammy thunder against torment torture trial tribulation trouble troubles vale of tears vexation vicissitude vilify violate visitation voodoo wanga waters of bitterness weigh down weight weird whammy woe wound wreak havoc on wrong