1. (n.) Grief; sorrow; misery; heavy calamity.

2. (n.) A curse; a malediction.

3. (a.) Woeful; sorrowful.

abomination aching heart affliction agony agony of mind anguish atrocity bad bale bane befoulment bemoaning bewailing bitter cup bitter draft bitter draught bitter pill bitterness bleeding heart blight broken heart bugbear burden burden of care calamity cankerworm of care care carking care cataclysm catastrophe corruption cross crown of thorns crushing crushing burden crying evil curse damage death defilement depression depth of misery desolation despair despoliation destruction detriment disease distress dole encumbrance evil extremity gall gall and wormwood grief grievance harm havoc heartache heartbreak heartfelt grief heartgrief heavy heart hurt ill infection infelicity infliction injury lamentation languishment load melancholia melancholy misadventure mischief misery nemesis open wound oppression outrage pack of troubles peck of troubles pest pestilence pining plague poison pollution prostration regret rue running sore sadness scourge sea of troubles sorrow sorrowing suicidal despair the worst thorn torment toxin tragedy trouble unhappiness venom vexation visitation waters of bitterness weight wretchedness wrong