1. (n.) Lack of ease; uneasiness; trouble; vexation; disquiet.

2. (n.) An alteration in the state of the body or of some of its organs, interrupting or disturbing the performance of the vital functions, and causing or threatening pain and weakness; malady; affection; illness; sickness; disorder; -- applied figuratively to the mind, to the moral character and habits, to institutions, the state, etc.

3. (v. t.) To deprive of ease; to disquiet; to trouble; to distress.

4. (v. t.) To derange the vital functions of; to afflict with disease or sickness; to disorder; -- used almost exclusively in the participle diseased.

affection affliction ailment bane blight bug bugbear burden calamity cancer complaint condition contagion contaminate crushing burden curse death debility decrepitude destruction disability disorder epizootic evil feebleness grievance harm ill illness infect infection infirmity infliction malady malaise misery murrain nemesis open wound pest pestilence plague running sore scourge sickliness sickness syndrome taint thorn torment unhealthiness vexation virus visitation woe