1. (n.) An ailment; a disease; a imperfection in body or character\; esp., an unsound, unhealthy, or debilitated state; a disease; a malady; as, infirmity of body or mind.

2. (n.) A personal frailty or failing; foible; eccentricity; a weakness or defect.

abnormality abulia acute disease advanced age advanced years affection affliction age of retirement ailment allergic disease allergy an incurable disease anility atrophy bacterial disease bad habit besetting sin birth defect blemish blight bug cachexia cachexy caducity cardiovascular disease catch chronic disease chronic ill health circulatory disease complaint complication condition congenital defect cowardice crack danger debilitation debility decay decline of life declining years decrepitude defect defection deficiency deficiency disease deformity degenerative disease delicacy delicate health desultoriness disability disease disorder distemper dotage drawback eld elderliness endemic endemic disease endocrine disease enervation enfeeblement epidemic disease exhaustion failing failure faintheartedness faintness fault faute fear feeblemindedness feebleness flaw foible fragility frailness frailty functional disease fungus disease gastrointestinal disease genetic disease green old age hale old age handicap hazard healthlessness hereditary disease hoary age hole hypochondria hypochondriasis iatrogenic disease ill ill health illness imperfection inadequacy incapacity indisposition infectious disease infirm old age infirmity of age insecurity insipidity insolidity instability insubstantiality invalidism invalidity kink languishing languishment little problem longevity malady malaise moral flaw morbidity morbidness morbus muscular disease neurological disease nutritional disease occupational disease old age oldness organic disease pandemic disease pathological condition pathology peakedness pensionable age peril perilousness plant disease pliability poor health precariousness problem protozoan disease psychosomatic disease respiratory disease ricketiness rift ripe old age risk riskiness rockiness second childhood secondary disease seediness senectitude senility senior citizenship shakiness shiftiness shiftingness shortcoming sickishness sickliness sickness signs slipperiness snag softness something missing speculativeness spinelessness superannuation symptomatology symptomology symptoms syndrome taint the downward slope the golden years the pip ticklishness treacherousness treachery unauthenticity unauthoritativeness undependability unfaithworthiness unfirmness unhealthiness unreliability unsolidity unsoundness unsteadfastness unsteadiness unsturdiness unsubstantiality unsureness untrustworthiness unwholesomeness urogenital disease vale of years valetudinarianism vapidity vice virus disease vulnerable place wasting wasting disease wateriness weak link weak point weak side weak will weak-mindedness weakening weakliness weakness white hairs wishy-washiness worm disease