1. (a.) Sorrow; mental suffering\ arising from any cause, as misfortune, loss of friends, misconduct of one's self or others, etc.; sorrow; sadness.

2. (a.) Cause of sorrow or pain; that which afflicts or distresses; trial; grievance.

3. (a.) Physical pain, or a cause of it; malady.

accident ache aching aching heart adversity affliction agony agony of mind anguish apologies attrition ayenbite of inwit bale bemoaning bewailing bitterness bleakness bleeding heart blow broken heart burden calamity care carking care casualty cataclysm catastrophe cheerlessness collision come apart come to grief come unstuck comfortlessness contretemps contriteness contrition crack-up cramp crash crushing curse cut dejection depression depth of misery desolation despair despondency difficulty disaster discomfort dismalness distress distressfulness dole dolor dreariness extremity fail grievousness heartache heartbreak heartfelt grief heartgrief heavy heart hurt ill hap infelicity injury joylessness lamentability lamentation lamenting languishment lesion load melancholia melancholy misadventure miscarry mischance misery misfortune mishap mournfulness nasty blow onus ordeal pain painfulness pang passion pathos pileup pining pitiability pitiableness pitifulness poignancy prostration regret regretfulness regrets regrettableness regretting remorse remorse of conscience remorsefulness repining rue ruth sadness shame shamefacedness shamefastness shamefulness sharpness shipwreck shock smash smashup sore sore spot sorriness sorrow sorrowfulness sorrowing spasm staggering blow stress stress of life stroke suffering suicidal despair tender spot throes torment tragedy trauma travail trial tribulation trouble unhappiness wistfulness woe woebegoneness woefulness worry wound wreck wrench wretchedness