1. (n.) The uneasiness or pain of mind which is produced by the loss of any good, real or supposed, or by disappointment in the expectation of good; grief at having suffered or occasioned evil; regret; unhappiness; sadness.

2. (n.) To feel pain of mind in consequence of evil experienced, feared, or done; to grieve; to be sad; to be sorry.

ache adversity afflict affliction aggrieve agonize agony anguish apologies attrition ayenbite of inwit bad luck bemoan bemoaning bewail bewailing bitter cup bitter draft bitter draught bitter pill bitterness bleed break down bring to tears brood over burden burden of care cankerworm of care care cares carking care contriteness contrition cross crown of thorns crush curse cut up dejection deplore depression desolate desolateness desolation dirge discomfort dismay distress dole dolor draw tears elegize embitter encumbrance fret gall gall and wormwood give sorrow words grief grievance grieve grieving groan hard luck hardship heartache heartbreak heartfelt grief heartgrief howling infliction inundate keen keening knell lament lamentation lamenting languishment load melancholy misery misfortune moan moaning mope mourn mourning oppress oppression overwhelm pack of troubles pain peck of troubles pine pine away pining pressure prostrate prostration regret regretfulness regrets regretting remorse remorse of conscience remorsefulness repine repining rue sadness sea of troubles shame shamefacedness shamefastness shamefulness sigh sing the blues sob sorriness sorrowfulness sorrowing strain suffering take on thorn torment travail trial tribulation trouble ululation unhappiness wailing waters of bitterness weep over weight wistfulness woe wretchedness