(n.) Sorrow; anguish of mind; mental pang.

aching heart affliction agony agony of mind anguish bale bitterness bleeding heart broken heart brokenheartedness care crushing depression depth of misery desolation despair dole extremity grief heartbreak heartbrokenness heartsickness heartsoreness heavy heart infelicity melancholia melancholy misery prostration regret rue sadness suicidal despair woe wretchedness