1. (n.) Great unhappiness; extreme pain of body or mind; wretchedness; distress; woe.

2. (n.) Cause of misery; calamity; misfortune.

3. (n.) Covetousness; avarice.

Cassandra Schmerz ache aches and pains aching heart adversity affliction agony agony of mind angst anguish anxiety bale bitterness bleeding heart broken heart burden calamity care carking care catastrophe cheerlessness crushing curse cynic dampener damper dejection depression depth of misery desolation despair desperation despondency destitution disaster discomfort discontent displeasure distress dolor extremity gloom gloomy Gus grief grimness grouch grump hardship heartache heartfelt grief heartgrief heavy heart humorlessness hurt hurting indigence infelicity infestivity joylessness killjoy lamentation languishment malaise malcontent melancholia melancholy mirthlessness misfortune ordeal pain pang passion penury pessimist pining poverty privation prophet of doom prostration sadness sordidness sorrow sorrowing sourpuss spoilsport squalor stitch suffering suicidal despair throe trial tribulation trouble twinge uncheerfulness unhappiness unjoyfulness unmirthfulness wet blanket woe wretchedness