(n.) An indefinite feeling of uneasiness, or of being sick or ill at ease\.

Schmerz Slough of Despond abnormality aches and pains acute disease affection affliction agitation ailment all-overs allergic disease allergy angst anguish anxiety anxiety hysteria anxiety neurosis anxious bench anxious concern anxious seat anxiousness apprehension apprehensiveness atrophy bacterial disease birth defect blank despondency blight bluster bobbery boil boiling boredom brouhaha bustle cankerworm of care cardiovascular disease care cheerlessness chronic disease churn circulatory disease commotion complaint complication concern concernment condition congenital defect conturbation death wish debility decrepitude defect deficiency disease deformity degenerative disease dejectedness dejection depression despair despondency despondentness disability discomfort discomposure discontent discouragement disease disheartenment dislike disorder dispiritedness displeasure disquiet disquietude dissatisfaction distemper distress disturbance dolor down trip downcastness downer downheartedness dread drooping spirits dullness ebullition embroilment emptiness endemic endemic disease endocrine disease ennui epidemic disease excitement existential woe fear feebleness ferment fermentation fever feverishness fidgets flap flatness flurry fluster flutteration foment foreboding forebodingness fume functional disease fungus disease fuss gastrointestinal disease genetic disease grimness handicap heartlessness hereditary disease hopelessness hubbub hurly-burly hurt hurting iatrogenic disease illness indisposition infectious disease infirmity inquietude jitters joylessness jumpiness lack of pleasure low spirits lowness lowness of spirit maelstrom malady misery misgiving moil morbidity morbus muscular disease nausea nerviness nervosity nervous strain nervous tension nervousness neurological disease nongratification nonsatisfaction nutritional disease occupational disease oppression organic disease overanxiety pain painfulness pandemic disease pathological condition pathology perturbation pessimism pins and needles plant disease protozoan disease psychosomatic disease pucker respiratory disease restlessness rockiness roil rout row savorlessness secondary disease seediness seethe seething self-destructive urge sickishness sickliness sickness signs sinking heart solicitude spiritlessness spleen staleness stew stir strain suffering suicidal despair suspense swirl symptomatology symptomology symptoms syndrome taedium vitae tastelessness tediousness tedium tension the pip to-do trepidation trepidity trouble tumult tumultuation turbidity turbulence turmoil twitter uncomfortableness unease uneasiness unhappiness unhealthiness unpleasure unquietness unrest unsatisfaction upset urogenital disease vexation vexation of spirit virus disease wasting disease weariness of life worm disease zeal