1. (n.) The act of vexing, or the state of being vexed; agitation; disquiet; trouble; irritation.

2. (n.) The cause of trouble or disquiet; affliction.

3. (n.) A harassing by process of law; a vexing or troubling, as by a malicious suit.

abomination affliction aggravation agitation all-overs angst annoyance anxiety anxiety hysteria anxiety neurosis anxious bench anxious concern anxious seat anxiousness apprehension apprehensiveness atrocity bad bad news bane bedevilment befoulment blight bore bother botheration bothering bothersomeness bugbear burden calamity cankerworm of care care concern concernment corruption crashing bore crushing burden crying evil curse damage death defilement despoliation destruction detriment devilment difficulty disapprobation disapproval discontent disease displeasure disquiet disquietude dissatisfaction distress disturbance dogging downer drag dread evil exasperation fear foreboding forebodingness grievance harassment harm harrying havoc headache hounding hurt ill infection infliction injury inquietude irking irritation malaise mischief misgiving molestation nemesis nervous strain nervous tension nervousness nuisance open wound outrage overanxiety persecution perturbation pest pestilence pins and needles plague poison pollution problem provocation provoking pucker resentfulness resentment running sore scourge solicitude stew strain suspense tension the worst thorn torment toxin trial trouble uneasiness unquietness upset venom vexatiousness vexing visitation woe worriment worry wrong zeal