abnormality abstruseness action acute disease affection affliction ailment allergic disease allergy anagnorisis angle architectonics architecture arduousness argument atmosphere atrophy background bacterial disease bind birth defect blight bothersomeness burdensomeness cardiovascular disease catastrophe characterization chronic disease circulatory disease clutch color complaint complexity complexness condition congenital defect continuity contrivance convolution crabbedness crampedness crunch deepness defect deficiency disease deformity degenerative disease denouement design development device difficultness difficulty dilemma disability disease disorder distemper drawback embarrassing position embarrassment endemic endemic disease endocrine disease entanglement epidemic disease episode esoterica fable falling action fine how-do-you-do functional disease fungus disease gastrointestinal disease genetic disease gimmick hairiness handicap hardness hell to pay hereditary disease hobble hot water how-do-you-do iatrogenic disease illness imbroglio incident indisposition infectious disease infirmity intricacy intricateness involution involvement jam knottiness laboriousness line local color malady malaise mess mix mood morass morbidity morbus motif movement muscular disease mythos neurological disease nutritional disease obstacle obstruction occupational disease onerousness oppressiveness organic disease pandemic disease parlous straits pass pathological condition pathology peripeteia perplexity pickle pinch plan plant disease plight plot predicament pretty pass pretty pickle pretty predicament problem profoundness profundity protozoan disease psychosomatic disease quagmire quicksand ramification recognition reconditeness respiratory disease rigor rigorousness rising action rockiness ruggedness scheme scrape secondary disease secondary plot seediness sickishness sickness signs slant slough snag spot squeeze stew sticky wicket story strait straits strenuousness structure subject subplot subtlety swamp switch symptomatology symptomology symptoms syndrome tanglement technicality the pip thematic development theme tight spot tight squeeze tightrope toilsomeness tone topic toughness tricky spot troublesomeness twist unholy mess urogenital disease virus disease wasting disease worm disease