(n.) The state of desponding; loss of hope and cessation of effort; discouragement; depression or dejection of the mind.

Schmerz Slough of Despond acedia apathy blank despondency cave of Trophonius cave of despair death wish dejectedness dejection depression despair desperateness desperation despondentness disconsolateness discouragement disheartenment dispiritedness down trip downcastness downer downheartedness drooping spirits forlornness heartlessness hopelessness low spirits lowness lowness of spirit malaise no exit no way no way out oppression pessimism self-destructive urge sinking heart sloth spiritlessness suicidal despair taedium vitae weariness of life