1. (n.) Hopelessness; despondency; discouragement\.

2. (v. t.) To give up as beyond hope or expectation; to despair of.

3. (v. t.) To cause to despair.

4. (n.) Loss of hope; utter hopelessness; complete despondency.

5. (n.) That which is despaired of.

Schmerz Slough of Despond abandon abandon hope acedia aching heart agony agony of mind anguish apathy bale become suicidal bitterness blank despondency bleeding heart broken heart cave of Trophonius cave of despair crushing death wish dejectedness dejection depression depth of misery desolation despair of desperateness desperation despond despondency despondentness disconsolateness discouragement disheartenment dispiritedness distress down trip downcastness downer downheartedness droop drooping spirits drop extremity falter forlornness give up give up hope give way gloom gloominess grief heartache heartlessness heavy heart hit rock bottom hopelessness infelicity languish lose heart lose hope low spirits lowness lowness of spirit malaise melancholia melancholy miserableness misery no exit no way no way out oppression pessimism plumb the depths prostration quit reach the depths relinquish renounce resign resignation sadness self-destructive urge sink sink into despair sinking heart sloth spiritlessness suicidal despair surrender taedium vitae touch bottom weariness of life woe wretchedness yield yield to despair