1. (v. t.) To deprive of nerve, force, strength, or courage; render ineffective\; to impair the moral powers of.

2. (a.) Weakened; weak; without strength of force.

abate afflict attenuate beat blunt break burn out castrate cramp cripple damp dampen deaden debilitate defeat demasculinize dematerialize derange desex desexualize devitalize disable disembody disorder do in do up drain dull effeminize emasculate enfeeble etherealize etiolate eviscerate exhaust extenuate fag fag out fatigue flag frazzle gruel harass hospitalize incapacitate indispose invalid jade knock out knock up lay low lay up mitigate overfatigue overstrain overtire overweary poop poop out prostrate rarefy rattle reduce sap shake shake up sicken soften up spiritualize sterilize strain subtilize tire tire out tire to death tucker unbrace undermine unman unnerve unstrengthen unstring use up weaken wear wear down wear on wear out weary wilt wind