1. (v. t.) To put out of place, order, or rank; to disturb the proper arrangement or order of; to throw into disorder, confusion, or embarrassment; to disorder; to disarrange; as, to derange the plans of a commander, or the affairs of a nation.

2. (v. t.) To disturb in action or function, as a part or organ, or the whole of a machine or organism.

3. (v. t.) To disturb in the orderly or normal action of the intellect; to render insane.

afflict clutter craze debilitate dement devitalize disable disarrange disarray discommode discompose dishevel dislocate disorder disorganize distract disturb drive insane drive mad enervate enfeeble frenzy hospitalize incapacitate incommode inconvenience indispose invalid lay up litter mad madden make mad mess mess up misarrange muss muss up perturb reduce ruffle rummage rumple scatter send mad shatter sicken tousle turn unbalance unhinge unsettle upset weaken