Schmerz Slough of Despond blank despondency dejectedness dejection depression despair despondency despondentness discouragement disheartenment dispiritedness down trip downcastness downer downheartedness drooping spirits heartlessness hopelessness low spirits lowness lowness of spirit malaise oppression pessimism self-destructive urge sinking heart spiritlessness suicidal despair taedium vitae weariness of life