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adverse circumstances
adversity
affliction
aggravation
alteration
alternation
annoyance
asperity
blight
bummer
care
chain of circumstances
chain reaction
change
changeability
changes
chapter of accidents
chop and change
concatenation of events
contrasts
cross
curse
difficulties
difficulty
diversity
downer
feast and famine
fluctuation
flukiness
flux
hard knocks
hard life
hard lot
hardcase
hardness
hardship
inconstancy
innovation
ins and outs
irritation
mischance
misfortune
mutability
mutation
novelty
oscillation
pendulation
permutation
plight
predicament
pressure
progression
reversal
rigor
sea of troubles
seesawing
shifting
shuffling
sport
stress
stress of life
teeter-tottering
teetering
tottering
transposition
trial
tribulation
trouble
troubles
unpredictability
ups and downs
vacillation
vale of tears
variability
variation
variations
variety
vicious circle
vicissitudes
vicissitudes of fortune
wavering
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