1. (v.) To reduce; to lessen; to exhaust; as to deplete a country of its resources, a treasury of money\, etc.

2. (v.) To empty or unload, as the vessels of human system, by bloodletting or by medicine.

ablate absorb assimilate bankrupt bleed bleed white blow blow out burn up clean out clear clear away clear off clear out clear the decks consume cripple debilitate decrease defecate depreciate dig into digest diminish disable dissipate drain drain of resources draw draw down draw off dribble away dry up eat eat up eliminate empty empty out enfeeble erode evacuate exhaust expend finish finish off gobble gobble up impoverish ingest lessen milk purge reduce remove sap scour out shrink spend squander suck dry swallow swallow up sweep out unclog undermine unfoul use up vent void wash up waste waste away weaken wear wear away