1. (a.) Affected with spleen; malicious; spiteful; peevish; fretful.

2. (n.) A person affected with spleen.

acerb acerbate acerbic acid acidic acidulent acidulous acrimonious adrenal bearish bitchy bitter blase burning cankered cantankerous caustic choleric churlish crabbed cranky cross cross-grained crusty cussed disagreeable dispirited eccrine embittered endocrine excitable exocrine fed-up feisty fractious glandular glandulous gonadal good and tired holocrine huffish huffy humoral irascible irked irritable jaded life-weary luteal mean melancholic melancholy merocrine ornery ovarian pancreatic perverse prostatic rancorous rankled resentful resenting satiated sick sick of snappish sore spiteful spleeny stewing testy thymic thyroidal tired tired of tired of living tired to death ugly virulent waspish wearied weariful weary weary unto death world-weary