1. (v. i.) To give up, to lose courage or spirit\; to be thoroughly disheartened; to lose all courage; to become dispirited or depressed; to take an unhopeful view.

2. (n.) Despondency.

abandon hope become suicidal brood despair despair of droop falter give up give up hope give way hit rock bottom languish lose heart lose hope plumb the depths reach the depths sag sink sink into despair touch bottom yield to despair