JOSEPH MERRET, now an Under Gardener to the Earl of Berkeley, lived as a Servant with a Farmer near this place in the year 1770, and occasionally assisted in milking his master's cows. Several horses belonging to the farm began to have sore heels, which Merret frequently attended. The cows soon became affected with the Cow Pox, and soon after several sores appeared on his hands. Swellings and stiffness in each axilla followed, and he was so much indisposed for several days as to be incapable of pursuing his ordinary employment. Previously to the appearance of the distemper among the cows there was no fresh cow brought into the farm, nor any servant employed who was affected with the Cow Pox.

In April, 1795, a general inoculation taking place here, Merret was inoculated with his family; so that a period of twenty-five years had elapsed from his having the Cow Pox to this time. However, though the variolous matter was repeatedly inserted into his arm, I found it impracticable to infect him with it; an efflorescence only, taking on an erysipelatous look about the centre, appearing on the skin near the punctured parts. During the whole time that his family had the Small Pox, one of whom had it very full, he remained in the house with them, but received no injury from exposure to the contagion.

It is necessary to observe, that the utmost care was taken to ascertain, with the most scrupulous precision, that no one whose case is here adduced had gone through the Small Pox previous to these attempts to produce that disease.

Had these experiments been conducted in a large city, or in a populous neighbourhood, some doubts might have been entertained; but here, where population is thin, and where such an event as a person's having had the Small Pox is always faithfully recorded, no risk of inaccuracy in this particular can arise.