(v. t.) To make bitter or sad. See Imbitter.

acerbate afflict agent provocateur aggravate aggrieve alienate amplify anguish annoy antagonize arouse augment bitter break down bring to tears bristle build up chafe crush cut up damage deepen desolate deteriorate dilapidate draw tears endamage enhance enlarge envenom estrange exacerbate exasperate fret grieve harm heat up heighten hot up huff hurt impair incense increase inflame infuriate injure intensify inundate irritate madden magnify make acute make worse miff nettle oppress overwhelm peeve pique prostrate provoke put back rankle rile roil ruffle set against set at odds set up sharpen sorrow sour stir the blood stir up torment vex weaken work up worsen