Quotes
“Ageing is so many different things, and cells being able to self-renew is part of the picture but not all of it.”
“As maize became important for human food worldwide, modern agricultural research on maize breeding continued the corn breeding begun thousands of years ago in the Central American highlands.”
“Biology sometimes reveals its fundamental principles through what may seem at first to be arcane and bizarre.”
“Cancer cells have a lot of other things that are really wrong with them, and we should never forget that these are cells that have become deaf to all the signals that the body sends out, such as you can multiply a certain amount, you can be in a certain place in the body, where to stay, where to move, and so on.”
“Challenges in medicine are moving from 'Treat the symptoms after the house is on fire' to 'Can we preserve the house intact?'”
“Exercise mitigates the effects of stress - and stress, we know, shortens telomeres. In fact, early studies indicate that stress reduction techniques like meditation help people maintain the length of their telomeres.”
“For me, arguably the story of telomeres and telomerase began thousands of years ago, in the cornfields of the Maya highlands of Central America.”
“Generally, we try to have a situation where the person is healthy, so you're not confounded by disease. So, that means that healthy individuals are donating their blood samples for the studies.”
“I chose biochemistry as my major and graduated after 4 years with an Honours degree in Biochemistry. During that time, I had come to love biochemistry research, although I was just getting my feet wet in laboratory research.”
“I spent my first 4 years living in the tiny town of Snug, by the sea near Hobart. Curious about animals, I would pick up ants in our backyard and jellyfish on the beach.”
“I was born in the small city of Hobart in Tasmania, Australia, in 1948. My parents were family physicians. My grandfather and great grandfather on my mother's side were geologists.”
“I was using very unconventional methods to sequence the telemetric DNA, originally.”
“In my early work, our molecular views of telomeres were first focused on the DNA.”
“In my lab, we're finding that psychological stress actually ages cells, which can be seen when you measure the wearing down of the tips of the chromosomes, those telomeres.”
“In the 1970s, I did a Ph.D. with Fred Sanger in Cambridge who was in the process of inventing ways to map what's inside DNA. He later won the Nobel Prize.”
“I've only actively promoted what we always hope is good science.”
“Medicine has been successful by treating diseases in a very specific way once the damage is done. But telomere length integrates a lot of factors together and gives you an overall picture of risk for what is now emerging as a lot of diseases that tend to occur together, such as diabetes and heart disease.”
“Observational studies show that exercise, nutritional supplements and reducing psychological stress can help. Chronic high stress and smoking can lead to accelerated telomere shortening.”
“Perhaps arising from a fascination with animals, biology seemed the most interesting of sciences to me as a child.”
“Researchers have found that the brain definitely sends nerves directly to organs of the immune system and not just to the heart and the lower gut. In that way, too, the brain is influencing the body.”
“Telomeres are the protective caps at the ends of chromosomes in cells. Chromosomes carry the genetic information. Telomeres are buffers. They are like the tips of shoelaces. If you lose the tips, the ends start fraying.”
“The conservative statement is that telomere length is a biomarker, but it's probably not passive. There are some very intimate relationships between things such as molecular markers for inflammation and telomere health.”
“Tracing the beginnings of the interwoven stories of science can be arbitrary, as beginnings are so often lost in the mists of time.”
“We and other groups are seeing clear statistical links between telomere shortness and risk for a variety of diseases that are becoming very common, such as cardiovascular disease, diabetes and certain cancers.”
“We think there are lifestyle factors that boost telomerase naturally.”
“What is it that keeps you so interested in the telomere? It's so intricate and complicated, and you want to know how it works.”