CONTENTS.

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Page.
Introduction 5
Historical review of the literature on the toxicity of caffein 9
Acute caffein intoxication 18
Experiments on rabbits 18
Subcutaneous injection 18
Administration by mouth 26
Injection into the peritoneal cavity 28
Intramuscular injection 33
Intravenous injection 37
Summary 42
Experiments on guinea pigs 43
Subcutaneous injection 43
Injection into the peritoneal cavity 47
Administration by mouth 49
Summary 52
Experiments on cats 53
Subcutaneous injection 53
Injection into the peritoneal cavity 56
Administration by mouth 57
Summary 59
Experiments on dogs 60
Administration by mouth 60
Subcutaneous injection 60
Experiments on puppies 61
Summary 62
Chronic caffein intoxication 63
Experiments on rabbits 63
Experiments on dogs 75
Discussion of results 91
General summary and conclusions 95
Bibliography 97

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[Pg 5]

THE TOXICITY OF CAFFEIN.


                                                                                                                                                                                                                                                                                                           

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