Plague is known in Europe, Asia and Africa, but it has not been known in the Western Hemisphere. It is said that Mesopotamia is the home of plague. It has been known as far North as Astrakhan in Asia and Norway in Europe. During the last fifty years, however, it is chiefly confined to Asia from Red Sea on one side, and the shores of the Pacific on the other. Some are inclined to think that the plague was carried from Himalyan India across Thibet to Yanon in Chinese territory, thence to Pekoi whence it made its way to Canton and Hongkong. If that be so, then the plague has accomplished a tour from Northern India vi China by Sea route to Southern India within a period of twenty years between 1876 and 1896.