April 5th. Several children and adults were inoculated from the arm of William Pead. The greater part of them sickened on the 6th day, and were well on the 7th, but in three of the number a secondary indisposition arose in consequence of an extensive erysipelatous inflammation which appeared on the inoculated arms. It seemed to arise from the state of the pustule, which spread out, accompanied with some degree of pain, to about half the diameter of a six-pence. One of these patients was an infant of half a year old. By the application of mercurial ointment to the inflamed parts (a treatment recommended under similar circumstances in the inoculated Small-pox) the complaint subsided without giving much trouble.

HANNAH EXCELL an healthy girl of seven years old, and one of the patients above mentioned, received the infection from the insertion of the virus under the cuticle of the arm in three distinct points. The pustules which arose in consequence, so much resembled, on the 12th day, those appearing from the insertion of variolous matter, that an experienced Inoculator would scarcely have discovered a shade of difference at that period. Experience now tells me that almost the only variation which follows consists in the pustulous fluids remaining limpid nearly to the time of its total disappearance; and not, as in the direct Small-pox, becoming purulent.–(See Plate, No. 4.) Plate 4