Nothing appears to be known of the parentage and birth of John Ratcliffe, the collector, who for some years kept a chandler's shop in Southwark, where he seems to have amassed a sufficient competency to enable him to retire from business and devote the remainder of his life to the acquisition of old books. It is said that his passion for collecting them arose from the perusal of some of the volumes which were purchased by him for the purpose of wrapping his wares in. Ratcliffe kept his library at his house in East Lane, Bermondsey, where, Nichols informs us in his Literary Anecdotes, 'he used to give Coffee and Chocolate every Thursday morning to Book and Print Collectors; Dr. Askew, Messrs. Beauclerk, Bull, Croft, Samuel Gillam, West, etc., used to attend, when he would produce some of his fine purchases.' Nichols adds, 'he generally used to spend whole days in the Booksellers' warehouses; and, that he might not lose time, would get them to procure him a chop or a steak.' An amusing letter respecting him appeared in the Gentleman's Magazine for 1812. The writer states that 'Mr. John Radcliffe was neither a man of science or learning. He lived in East Lane, Bermondsey; was a very corpulent man, and his legs were remarkably thick, probably from an anasarcous complaint. The writer of this remembers him perfectly well; he was a very stately man, and, when he walked, literally went at a snail's pace. He was a Dissenter, and every Sunday attended the meeting of Dr. Flaxman in the lower road to Deptford. He generally wore a fine coat, either red or brown, with gold lace buttons, and a fine silk embroidered waistcoat, of scarlet with gold lace, and a large and well-powdered wig. With his hat in one hand, and a gold-headed cane in the other, he marched royally along, and not unfrequently followed by a parcel of children, wondering who the stately man could be. A few years before his death, a fire happened in the neighbourhood where he lived; and it became necessary to remove part of his household furniture and books. He was incapable of assisting himself; but he stood in the street lamenting and deploring the loss of his Caxtons, when a sailor, who lived within a few doors of him attempted to console him: "Bless you, Sir, I have got them perfectly safe!" While Ratcliffe was expressing his thanks, the sailor produced two of his fine curled periwigs, which he had saved from the devouring element; and who had no idea that Ratcliffe could make such a fuss for a few books.' He died in 1776.

Ratcliffe's collection, though not large, was marvellously rich in the productions of the early English printers; and the volumes were generally in fine condition, and handsomely bound, though not always in good taste. It contained no less than forty-eight Caxtons, among which were the Game of the Chesse, the Dictes or Sayings of the Philosophers, the History of Jason, and Chaucer's Canterbury Tales. It comprised also numerous books from the presses of the Schoolmaster of St. Albans, Lettou, Machlinia, Pynson, Wynkyn de Worde, etc., and a few manuscripts. Dibdin in his Bibliomania remarks: 'If ever there was a unique collection, this was one—the very essence of Old Divinity, Poetry, Romances and Chronicles.' Ratcliffe compiled a manuscript catalogue of his library in four volumes, which was disposed of at the sale of his collection for seven pounds, fifteen shillings. It is said that he always wrote on the first fly-leaf of his books 'Perfect'—or otherwise, as the case might be.

After his death his library was sold by auction by Mr. Christie of Pall Mall. The sale, which commenced on the 27th of March 1776 and lasted till April 6th, consisted of one thousand six hundred and seventy-five lots. It does not appear to have been well managed, for Nichols says, 'there were many hundred most rare Black-letter books and Tracts, unbound, with curious cuts. They were sold I remember in large bundles, and were piled under the tables in the Auction Room, on which the other books were exposed to view, and were not seen by the Booksellers who were the purchasers.' A priced copy of the catalogue is preserved in the British Museum, which shows that the Caxtons fetched but two hundred and thirty-six pounds, five shillings and sixpence; the highest prices obtained being sixteen pounds for the Game of the Chesse, fifteen guineas for the Dictes or Sayings of the Philosophers, and nine pounds, fifteen shillings for the Golden Legende. King George III. bought twenty of the Caxtons at an aggregate cost of about eighty-five pounds. Among them were the De Consolatione PhilosophiÆ of Boethius, Reynard the Foxe, the Golden Legende, the Curial, and the Speculum VitÆ Christi. The Boethius, which was a fine copy, was acquired for four pounds, six shillings. A copy of the Bokys of Hawkyng and Huntyng, etc., ascribed to Dame Juliana Bernes, printed at St. Albans in 1486, sold for nine pounds, twelve shillings, and a manuscript Bible on vellum, finely illuminated, for two pounds, ten shillings.