PAGE
INTRODUCTION 1
Definition. Clinical methods of investigation of the blood 1
The quantity of the blood 2
Number of red corpuscles 4
Size of red corpuscles 12
Amount of hÆmoglobin in the blood 13
Specific gravity of the blood 17
Hygrometry 21
Total volume of the red corpuscles 21
Alkalinity of the blood 23
Coagulability of the blood 24
Separation of the serum 24
Resistance of the red corpuscles 25
THE MORPHOLOGY OF THE BLOOD 27
A. Methods of investigation 29
a. Preparation of the dry specimen 32
. Fixation of the dry specimen 34
?. Staining of the dry specimen 36
Theory of staining 37
Combined staining 38
Triacid fluid 40
Other staining fluids 41
Recognition of glycogen in the blood 45
Microscopic determination of the distribution of the alkali of the blood 46
B. Normal and pathological histology of the blood 48
The red blood corpuscles 48
Diminution of hÆmoglobin equivalent 49
AnÆmic or polychromatophil degeneration 49
Poikilocytosis 52
Nucleated red blood corpuscles 54
Normoblasts and megaloblasts 56
The fate of the nuclei of the erythroblasts 57
The clinical differences in the erythroblasts 61
THE WHITE BLOOD CORPUSCLES 67
I. Normal histology and classification of the white blood corpuscles 71
The lymphocytes 71
The large mononuclear leucocytes 73
The transitional forms 74
The polynuclear leucocytes 75
The eosinophil cells 76
The mast cells 76
Pathological forms of white blood corpuscles 77
The neutrophil myelocytes 77
The eosinophil myelocytes 78
The neutrophil pseudolymphocytes 78
Stimulation forms 79
II. On the places of origin of the white blood
corpuscles 81
a. The spleen 84
. The lymphatic glands 100
?. The bone-marrow 105
III. On the demonstration of the cell-granules,
and their significance 121
History of the investigation of the granules 121
Since Ehrlich. 123
Methods of demonstration 124
Vital staining of granules 124
The Bioblast theory (Altmann) 128
The granules as metabolic products of the cells (Ehrlich) 130
Secretory processes in granulated cells 134
IV. Leucocytosis 138
Biological importance of leucocytosis 138
Morphology of leucocytosis 142
a. 1. Polynuclear neutrophil leucocytosis 143
Definition 143
Clinical occurrence 144
Origin 144
a. 2. Polynuclear eosinophil leucocytosis, including
the mast cells 148
Definition 149
Clinical occurrence 150
Origin 154
. LeukÆmia ("mixed leucocytosis") 167
Lymphatic leukÆmia 170
Myelogenous leukÆmia 171
Morphological character 187
Origin 187
V. Leukopenia 188
The blood platelets. The hÆmoconiÆ 190
Index To Literature 195
Index 209
Plates