  U. S. Department of Agriculture, Bureau of Plant Industry, Sir: I have the honor to transmit herewith the manuscript of a technical bulletin entitled “Barium, a Cause of the Loco-Weed Disease,” prepared by Dr. A. C. Crawford, Pharmacologist, under the direction of Dr. Rodney H. True, Physiologist in Charge of Poisonous-Plant Investigations, and to recommend that it be published as Bulletin No. 129 of the series of this Bureau. For many years the stockmen in many parts of the West have reported disastrous consequences following the eating of so-called loco weeds characteristic of the regions involved. While many have doubted any causal relation between the plants in question and the stock losses, the reality of the damage has remained and has seemed to require a thoroughgoing sifting of the evidence concerning the part played by the plants. Accordingly, in the spring of 1905 a station for the experimental study of the problem was established at Hugo, Colo., in charge of Dr. C. Dwight Marsh, Expert, in cooperation with the Colorado Agricultural Experiment Station. Later a further feeding experiment was undertaken at Imperial, Nebr., in cooperation with the Nebraska Agricultural Experiment Station. Parallel with the feeding work in the field, laboratory work, designed to test under laboratory conditions the poisonous action of the plants from given areas, was undertaken at Washington by Dr. A. C. Crawford, Pharmacologist. A further phase of his part of the work was an attempt to ascertain the nature of such poisonous substance or substances as might occur in the loco plants. In both of these lines of work Doctor Crawford has been successful, and the technical results of his work are here collected. Respectfully, |
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