Mr. Vice-president and Gentlemen,—In this, the concluding lecture of the series, I will attempt to deal with the applications of the facts and considerations which I submitted to you on the two previous occasions when I had the honour to address you. I trust that what I then laid before you proved to be of some interest. Let us see now whether it is practically useful. However much the Now, prognosis and treatment, to be rational and useful, have to be based on as full and as correct a diagnosis as knowledge permits. The present disposition is to fall short of this; to rest content with an incomplete diagnosis. We say that the patient's "heart is dilated," that he has "arterial degeneration," that there is "fatty degeneration." But you will remember that we have found that cardiac dilatation may be present in every kind of cardio-vascular degeneration; that the arteries are naturally enlarged and thickened after middle life, and that we refused to call these changes morbid. Clearly, therefore, a purely anatomical diagnosis of this sort is insufficient. If you are asked what the prognosis is of fatty degeneration of the heart, you answer that you must first be told whether syphilitic or gouty disease of the coronary arteries, or strain, or alcoholism, or phosphorus-poisoning or anÆmia is the cause of it. When you are planning the treatment of dilatation of the heart you first determine whether the dilatation is a result of the stretching of a sound heart by overfilling during muscular effort, or of the insufficient emptying of failing chambers with degenerated and feeble walls. Obviously what we ought to determine in these instances and in every instance is the origin of the disease. The ultimate diagnosis to be reached for practical purposes is the etiological diagnosis. Is this possible? Does our knowledge of the nature, characters and course of these cardio-vascular affections enable us to say, after investigating a case, what the kind of the pathological change is that constitutes the disease, or in what respect the physiological mechanisms are disordered? Can the cause of these degenerations of the heart and arteries be determined in each instance? How is the practitioner to proceed to do so? What method might be followed with advantage in making a complete diagnosis of heart disease in older subjects? A man of 60 consults us about his heart. He says that it has caused him a good deal of concern lately. More specifically he describes a sense of oppression behind the sternum as often as he exerts himself, and palpitation with consciousness of irregular We next proceed to physical examination, beginning with the pulse and arteries, and passing on to the heart and associated structures. The characters of the prÆcordial impulse—particularly the seat of the apex-beat and the strength of the impulse—are closely (I might almost say laboriously) investigated. We must never yield to the temptation to disregard weakness or absence of the impulse. Like many other negative signs it is apt to be overlooked. Then the prÆcordial dulness is mapped out by means of Now let us suppose that we have found a mitral systolic murmur. We ask ourselves whether it is structural or whether it is functional, that is, due to relaxation and dilatation of the ventricular walls. If structural, with which (if any) of the diseases elicited in the man's previous history would it correspond? Most probably with gout or glycosuria. Thus we attempt to connect the lesion with its cause, and the cause with its effects, and have reached the ultimate diagnosis. So with other valvular murmurs: for example, an aortic diastolic murmur proves to be related to syphilis. If there be no murmur audible, we naturally think of dilatation with failure, or of enlargement from strain, from Bright's disease, from arterial sclerosis, from emphysema, from an insufficient or impure blood-supply in the coronary arteries, from disordered innervation, or from some rarer cause, such as adherent pericardium; and then, with these associations in our minds, we review once more the patient's history, and generally succeed in our diagnosis. Here let me recount the significance of the principal signs and symptoms which I detailed to you in my last lecture, considered in the reverse order on this occasion, some of which are of real value in differentiating the causes of cardio-vascular degeneration. To begin with negative facts: a mitral pre-systolic murmur is never significant of a degenerative lesion. Secondly, when we meet with an aortic diastolic murmur, whether alone or along with an aortic systolic murmur, we may safely conclude that we have to deal with something more than atheroma produced by regular or irregular gout and associated metabolic disturbance, cardio-vascular disease of nervous origin and alcoholic or tobacco heart, even if there be evidence of the presence of one or more of these in the case. Aortic incompetence developed in later life is the result of syphilis, or of acute or chronic valvular strain; but, of course, many instances of this lesion met with after the age of 40 can be traced to juvenile endocarditis of rheumatic or other origin. Always a serious lesion, aortic incompetence due to syphilis, or to syphilis and strain, is particularly grave, as being so frequently associated with coronary Cardiac symptoms taken individually are of less diagnostic value than signs. No symptom is pathognomonic. Palpitation is a nearly universal phenomenon of cardiac disease and disorder. Faintness and actual faints are not uncommon in cases of early cardiac strain, gouty heart, and nervous disturbances. Angina we meet with, you will remember, in regular and irregular gout, tobacco heart, strain (especially strain after 40), and in syphilis and alcoholism, whilst pseudo-angina is extremely common in nervous women: thus angina is of less diagnostic value than might have been expected. A high-tension pulse I have found most often in Bright's disease, in juvenile strain, and in cardio-vascular affections of nervous origin; a low tension pulse in connection with alcoholic and tobacco poisoning, and with senile strain. When we review these facts, I think we are entitled to conclude that the physical signs and symptoms carefully determined by clinical investigation may be confidently employed, along with the patient's previous personal history, and the history of his present illness, to differentiate from each other the causes of cardio-vascular degeneration in individual cases. And, further, that they inform us of the seat of at least some of the lesions, valvular, parietal and vascular. A little trouble, patience and attentive observation are all that are required to reach a complete or working diagnosis. Now we may approach the great practical subjects of prognosis and treatment with some confidence. Prognosis.Beginning with the simplest kind of cardio-vascular disorder, let us see what the prognosis is in tobacco heart. You will have gathered from what I had to say on this subject in my last lecture, and indeed you know as men of observation and experience, that it is comparatively favourable. All the cases I have had an opportunity to watch did well, provided the cause of their distress was avoided and the heart and vessels were otherwise healthy. Further, improvement begins early, and it may be rapid and recovery complete; but you will remember that one patient, whose case I detailed to you, continued to have alarming angina for six months after giving up tobacco. Recurrence attends resumption of the habit, but some of its votaries contrive to continue to smoke just short of inducing serious discomfort. Unless a successful effort at reform be made, cardiac trouble may continue indefinitely. But even then I cannot say that I have seen serious damage done by tobacco alone in sound hearts, nor arterial sclerosis, as has been stated by some authorities. An entirely different and most unfavourable estimate is to be formed of the prospect of life in the alcoholic heart. Naturally, a certain proportion of cases recover if the disease be of recent development, the condition uncomplicated, and treatment faithfully carried out. Unfortunately, as a rule, we have to deal with alcoholism in which all these conditions of success are wanting. The habit is established, other organs besides the heart are involved, other diseases than alcoholism are present, and the patient has neither the inclination nor the power to follow our advice. Cirrhosis, neuritis, dementia complicate the cardiac degeneration, or, more correctly, it complicates one or all of these. Chronic Bright's disease is made to account for a number of deaths in the mortality returns that strictly belong to alcoholism. Occasionally the end comes suddenly from fatty degeneration, or in the course of some acute disease; otherwise, as we have seen, by slow cardiac failure and dropsy. Prognosis in gouty heart, including the heart of the man with goutiness, glycosuria and other irregular forms of the disease, is a subject of considerable practical difficulty. In my last lecture I read to you a short account of the case of a friend of my own who had had occasional attacks of gouty angina for 40 years. Still more unfavourable must be the forecast in syphilitic lesions of the heart and vessels. Of 18 of my cases in which the result was known, only one-half improved under treatment, and 20 per What prospect have we to hold out to the man who has strained the walls of his heart by muscular effort? I believe that one can speak with some confidence on this subject. The middle-aged patient who over-stretched his cardiac walls as a youth may be comforted with the opinion that the condition is not a fatal one. The average duration of 11 cases of this order I found to have been 30 years when they came under my observation; the minimum duration was nine years, the maximum 50 years. This last case deserves particular mention. The patient was first seen by me for failure of the heart with cardiac dropsy, consequent on fresh breakdown after exertion during a holiday; and it is most encouraging to observe that compensation was restored by treatment, and that now, 12 months after that event, he is not only alive, but able to carry on light professional work. This case also illustrates what I have told you respecting the course of the affection, and the prospect before the patients, in long-standing strain—that there is continual liability to fresh embarrassment of the heart during exertion, in which they appear to have a lasting inclination to indulge. If they happen to follow an occupation that entails occasional effort, or effort with excitement and worry (if they happen, let us say, to be busy practitioners of medicine), they suffer in the same way from attacks of tachycardia, distressing palpitation and anxiety. Indeed, as I pointed out in my second lecture, they are readily upset by other influences besides these, including indigestion, to which the victim of hurry and worry is peculiarly liable; and they must be prepared to have to lead a life of comparative temperance and self-denial. Neither is strain of the heart for the first time after 40 by any means so grave as might be expected. Of course, sudden muscular effort occasionally accounts for sudden death in old men. But it is astonishing how, under such circumstances, quite old persons do recover from conditions of extreme distress lasting acutely for half Cardio-vascular disorder and disease referable to nervous strain pure and simple is amenable to treatment by complete and prolonged rest or relaxation in the majority of instances. Still, death may occur from sudden cardiac failure; or should advice be neglected or soon forgotten, as happens so frequently in these subjects, the attendant high arterial tension and vascular degeneration too often end in cerebral lesions, with or without Bright's disease. Of chronic Bright's disease itself and the associated cardio-vascular changes in their prognostic aspects I need not speak, except to say that along with syphilis it is by far the most hopeless of all these affections. In attempting to forecast the life of a man who is the subject of cardio-vascular degeneration in middle or advanced life, we must not forget the possibility of the intercurrence of acute disease. Here is a large subject for us as practical men—one far too large and important for discussion here: the effect, for instance, of the existence of enlargement of the heart and an irregular and thickened pulse on the prognosis of influenza, or, let us say, on the chances of a successful issue after operation. Very naturally, unsound vessels and a murmur over the prÆcordia weigh heavily against the prospect of recovery from pneumonia, for example; and yet how often do we not find a patient of 70 with one or both of these disturbing conditions come safely through such an illness! Here, again, I believe it is in great measure the true nature of the old-standing disease, not the physical signs such as irregularity of pulse or mitral bruit, that ought to be taken into account. A heart enlarged and a radial artery thickened by prolonged activity and nothing else will suffice to carry a man safely through an attack of influenzal pneumonia; but what chance is there for the chronic alcoholic under similar circumstances, or for the subject of chronic Bright's disease? So much for the general prognosis in each of these kinds of cardio-vascular disorder and disease. But it is the particular prognosis that we have to attempt to estimate—that is, the Treatment.Not the least advantage of the etiological standpoint of our survey of the disorders and diseases of the heart and arteries in middle and advanced life is the rational as well as hopeful line of treatment which it enables us to pursue. On the whole, we can control morbific influences more easily than we can alter pathological processes; and (what is of equal or even greater importance) a knowledge of the causes of disease often enables us to prevent what we could not possibly cure. For all that, the etiology of heart disease furnishes us with but one set of many invaluable indications for treatment. We must have also a clear mental picture of the pathological anatomy of the conditions we would attempt to modify—for instance, of the damage wrought by gout on the mitral valves and aortic arch, by syphilis on the coronary arteries, by strain on the walls of the different cardiac chambers. No less necessary is it for the practitioner to take into account, before proceeding to prescribe, the clinical characters and course of the case in hand. As I have said more than once already, a large proportion of the distress, disabilities and dangers attending degeneration of the heart are due to some additional or extrinsic disturbance—distension of the stomach, constipation, worry or exertion—which alone, not the pathological condition, calls for therapeutical attention. It appears, then, that the whole natural history of the diseases and disorders of the heart—and, I might add, of every individual case—has to be studied, and the value of its different parts absolutely and relatively estimated, before rational treatment can be ordered. How different will treatment be, if ordered on these principles, from the routine procedure of prescribing a little strychnine and digitalis for a man with oppression on exertion and a systolic bruit at the base of his heart! Let us begin this part of our subject with a brief consideration of preventive treatment, founded on a knowledge of the cause at work. Now, the first thing to strike us about these unfavourable influences is the number of them that could be avoided or controlled successfully by simple exercise of the will. The toxic effects of tobacco, alcohol, tea, &c. are due to abuse, from thoughtlessness or ignorance, or from indisposition rather than inability to exercise self-control. The abuse of tobacco appears to create so much discomfort or even alarm, of a kind which the sufferer cannot fail to refer to its cause, that the remedy is effected automatically, and no great harm is done. We seldom have to do more than confirm the patient's suspicions in this direction, and recommend temporary abstinence from the cigarette or pipe and greater care in the future. With alcohol it is a different matter. Alcoholism grows by what it feeds on, and our best efforts are often vain. The present is hardly an occasion for dwelling on this subject—the duty of the profession to their patients and friends in respect of the abuse of alcohol. Still, I should not feel that I had discharged to the best of my ability, or in full conformity with my strong convictions, the duties of the honourable position which by your favour I occupy as Lettsomian Lecturer, if I did not urge you to exercise more fully than is at present exercised your personal influence to discourage habitual drinking. I believe (because I have found) that many men who are not open to arguments of an abstract kind, can be made to pause and reconsider their manner of living by having a concrete presentment of their condition and its results placed before them—in plain English, by being thoroughly frightened. "Heart disease" is a powerful argument to employ with persons of this class, and it is one that is also justified by the issues at stake. Of syphilis and the havoc that it works on heart, aorta and the vascular system generally, but particularly within the nervous system, I need not speak. The profession, as I have said, is not yet sufficiently alive to it: what can the public be expected to do in the way of prevention? Gout, corpulence and allied metabolic disorders, those fruitful sources of cardio-vascular disorders and atheroma, call for temperance not only in drinking but in eating. Whilst the question continues to be discussed which particular articles of food ought to be avoided by gouty individuals, let us all join in offering them one bit of advice of the value of which there can be no doubt: whatever they eat, to eat little. Moderation in amount is, speaking broadly, far more important than avoidance of the theoretical antecedents of uric acid, whether meat, or milk, I have already said so much on the subject of cardiac strain that it is unnecessary and would be uninteresting to return to the question of the prevention of it. We have seen how often it occurs in the middle-aged or old subject by ill-considered attempts at athleticism. Moderation and due respect for age are the true guides to the useful enjoyment of exercise after 40. As for the evil effects of nervous influences on the circulation, in addition to anxiety, care, misfortune and grief, which are usually beyond our control, nervous strain, as distinguished from simple hard intellectual work, often must be relaxed if cardio-vascular damage is to be prevented. I refer to the cases of persons in positions of great responsibility with heavy complex prolonged duties, which they fail to overtake without exhaustion consequent on high pressure and excitement. I would not have dwelt so long upon the measures calculated to prevent degeneration of the heart, were it not that they have to be employed with equal strictness and perseverance in the treatment of So much for valvular and vascular lesions. There remains to be discussed the fulfilment of the greater indication for treatment: the one which directs and governs the employment of the most important and successful of all the measures comprised in cardiac therapeutics. This is the establishment and maintenance of compensation. The nutrition and activity of the myocardium can be increased and sustained by means of specific cardiac stimulants and tonics, such as strychnine, ammonia and the digitalis group of drugs; by hÆmatinics, stomachics and laxatives to afford an abundant supply of healthy blood; by insuring wholesome nervous influences, one of the conditions of hypertrophy; and by the employment of the non-medicinal measures now so extensively used to increase the vigour and benefit the metabolism of the cardiac walls, particularly active and passive exercises and baths. This is a comprehensive statement of the lines of treatment calculated to benefit more or less all the kinds of cardiac degeneration which I have had occasion to notice. Of the individual pathological changes, and the rational treatment indicated for each from this point of view, I will refer to three only which will serve to illustrate the considerations which ought to guide us in practice. In the subject of regular or irregular gout attention to the cause, that is, to disordered metabolism of the body as a whole and of the cardiac and arterial walls in particular, promotes, as we have seen, the recognised conditions of compensation: the etiological and pathological indications are here practically identical. In respect of exercise in detail, gentle walking on the level should be ordered to begin with, that is, exercise short of producing pain or oppression. The patient had better give up his regular work for a time, and take advantage as fully as possible of the leisure to enjoy the benefits of a healthy life in the fresh open air. Very shortly he will be able to ride, play golf, shoot and cycle slowly. A course of treatment at one of the best of our native spas or of the Continental watering-places sometimes makes a new man of the sufferer from gouty heart. The Nauheim treatment, whether taken there or in England, may also do real good. But it must not be employed indiscriminately, as is so often done. The profession ought to remember (what the public cannot and probably never will come to understand) that pathological diagnosis must precede rational treatment, which consists in applying a proper remedy to the individual case before us, not in fitting every case to a specialised system or panacea—the essence of quackery. In planning the treatment of the dilated heart of the middle-aged man who strained his circulation in youth and comes to us complaining of a recurrence of prÆcordial distress and breathlessness, we have to remember that there is left in the cardiac walls but a portion of that reserve of elasticity and that reserve of muscular energy which they normally possess and require to enable them to meet the stress of exertion. Let me remind you for a moment that, of the provisions which the heart possesses against such an emergency or other sudden or severe demand upon its capacity and activity, one is extensibility of its tissues, by virtue of which it accommodates within it the considerable increase in the charge of blood that is poured into it from the active muscles, and the residues that accumulate within it from insufficient discharge in the face of increased peripheral resistance. The walls yield before the increased internal pressure acting on them both a tergo and a fronte; the heart is over-distended, with a passing sense of discomfort, dyspnoea and lividity; and when the muscular effort is ended the elasticity corresponding with extensibility of the walls presently insures the return of the chambers to their original dimensions. At the same time a second Compare with this line of treatment that which is indicated in acute cardiac strain after 40. The problem here is not how to deal with a chronically dilated and hypertrophied heart, but with a heart which has just yielded during effort, mainly in consequence of the nutritional impairment of its walls. It is not simply strain of a heart that had begun to be somewhat precariously nourished as a natural result of age; the probability is that the heart was actually I am on the point of passing from the subject of the nutrition of the myocardium, when it occurs to me that some of you might very naturally ask me: What about fatty degeneration and the treatment of it? This is a question peculiarly interesting to me. I have not dwelt on fatty degeneration of the heart in these lectures, and yet I have mentioned it again and again. I have said that it is a result of alcoholism, of gouty atheroma of the coronaries, of syphilitic arteritis in the same area, of Bright's disease, of profound anÆmia and of phosphorus poisoning; and that I believe it may result from severe nervous strain of a harassing and depressing character; and that in connection with each of these causes it has to be regarded and treated differently. Nothing could well bring home more fully to us the importance, indeed the necessity, of pursuing in practice the line of inquiry, prognosis and treatment which I have advocated in these lectures—the etiological one. Let me ask you also to listen to a confession of one of the highest authorities on heart disease in this country. "It is absolutely impossible," says Dr. George Balfour, "to diagnosticate fatty degeneration of the heart; we may surmise its existence, but we can only be certain of its presence when we see it post mortem"; and he quotes Fraentzel of Berlin in support of his I have now sketched very broadly the rational treatment of these disorders and diseases as far as the object of it is to prevent the occurrence or the extension of them, and to promote compensation of the disabilities which they produce. It remains for me to notice, also very briefly, the management of cardio-vascular degenerations when the heart fails, or when it appears to fail, and distress and danger demand more direct and immediate attention. I have said "when the heart appears to fail" of set purpose. I am anxious to direct your attention, if it be but for a moment, to the fact that in many instances where prÆcordial oppression, pain, palpitation and faintness, with frequent small irregular pulse, are significant of serious disturbance of the action of the heart, there is no failure of the myocardium in the proper sense of the term, but only embarrassment of a temporary character. Do not conclude from this that I regard the disturbance of the heart as of little account. I have called it serious, for indeed the patient may perish of it. What I wish to maintain is that in cardiac degeneration of any kind, in chronic cardiac dilatation, and in the enlarged heart of Bright's disease and of emphysema, just as in ordinary valvular disease, attacks of distress, alarming both to patient and doctor, often occur which call for nothing more in the way of treatment than attention to some intercurrent influence—an indigestible meal, loaded bowels, a nervous shock, a thoughtless effort, a passing hardship or nervous strain. Digitalis and its allies, strychnine, alcohol, nitrites, iodides and the rest are out of place in such an event. Complete rest in bed, a carminative draught, calomel and saline purgatives, spare and highly digestible diet, reassurance and a little time are quite sufficient means of treatment. When true failure occurs, manifested by the familiar phenomena of residual dilatation of the heart, mechanical congestion and dropsy, a different set of measures are demanded. Now is the time to attend with expedition, energy and completeness to the fulfilment And now I must bring these lectures to a close. In doing so I feel that I have not only to thank you, Sir, and the Fellows of the Medical Society and our visitors for the favour with which I have been received and the patience with which you have listened to me, but at the same time to apologise for the many defects, both in matter and in form, of what I have presented to you. It is a fortunate circumstance for me that, whilst the subject was so large and so difficult, the mode of treatment of it commonly associated with the Lettsomian Lectures and your kind forbearance have enabled me to conceal my shortcomings by free selection of less severely scientific topics, and the employment of an easy style. At the same time, may I claim a little of your favourable consideration for the aspect in which I have regarded the disorders and diseases of the heart and arteries in middle and advanced life? I should be satisfied with the results of my efforts on this occasion, whatever may be thought of their form, if I have succeeded in convincing you of the practical advantage of regarding these complaints from the side of their causes as well as of their pathological anatomy. Harrison and Sons, Printers in Ordinary to His Majesty, St. Martin's Lane. |