By the term PARASITES is understood living organisms which, for the purpose of procuring food, take up their abode, temporarily or permanently, on or within other living organisms. There are both plants and animals (Phytoparasites and ZoÖparasites) which lead a parasitic life in or upon other plants and other animals. Phytoparasites are not included in the following descriptions of the forms of parasitism, but a very large number of animal parasites (zoÖparasites) are described. The number of the latter, as a rule, is very much underrated. How great a number of animal parasites exists may be gathered from the fact that all classes of animals are subject to them. Some of the larger groups, such as Sporozoa, Cestoda, Trematoda and Acanthocephala, consist entirely of parasitic species, and parasitism even occurs among the vertebrates (Myxine). It therefore follows that the characteristics of parasites lie, not in their structure, but in the manner of their existence. Parasitism itself occurs in various ways and degrees. According to R. Leuckart, we should distinguish between OCCASIONAL (temporary) and PERMANENT (stationary) PARASITISM. Occasional parasites, such as the flea (Pulex irritans), the bed-bug (Cimex lectularius), the leech (Hirudo medicinalis), and others, only seek their “host” to obtain nourishment and find shelter while thus occupied. Without being bound to the host, they usually abandon the latter soon after the attainment of their object (Cimex, Hirudo), or they may remain on the body of their host throughout their entire development from the hatching of the egg (Pediculus). It follows from this mode of living that the occasional parasites become sometimes distinguishable from their free-living relatives, though only to a slight extent. It is, therefore, seldom difficult to determine the systematic position of temporary parasites from their structure. In consequence of their mode of life, all these temporary parasites live on the external surface of the body of their host, though more rarely they take up their abode in cavities easily accessible from the exterior, such as the mouth, nose and gills. They are therefore frequently called Epizoa or Ectoparasites; but these designations In contradistinction to these temporary parasites, the permanent parasites obtain shelter as well as food from their host for a long period, sometimes during the entire course of their life. They do not seek their host only when requiring nourishment, but always remain with it, thus acquiring substantial protection. The permanent parasites, as a rule, live within the internal organs, preferably in those which are easily accessible from the exterior, such as the intestine, with its appendages. Nevertheless, permanent parasites are also found in separate organs and systems, such as the muscular and vascular systems, hollow bones and brain, while some live on the outer skin. Here again, the terms Entozoa and Endoparasites do not include all stationary parasites; to the latter, for instance, the lice belong, which pass all their life on the surface of the body of their host, where they find shelter and food and go through their entire development. The ectoparasitic trematodes, numerous insects, crustacea, and other animals live in the same manner. All “Helminthes,” however, belong to the group of permanent parasites. This term is now applied to designate certain lowly worms which lead a parasitic life (intestinal worms); but they are not all so termed. For instance, the few parasitic Turbellaria are never classed with the helminthes, although closely related to them. The turbellarians, in fact, belong to a group of animals of which only a few members are parasitic, whereas the helminthes comprise those groups of worms of which all species (Cestoda, Trematoda, Acanthocephala), or at least the majority of species (Nematoda), are parasitic. Formerly the LinguatulidÆ (Pentastoma) were classed with the helminthes because their existence is also endoparasitic, and because the shape of their body exhibits a great similarity to that of the true helminthes. Since the study of the development of the LinguatulidÆ (P.J. van Beneden, 1848, and R. Leuckart, 1858) has demonstrated that they are really degenerate arachnoids, they have been separated from the helminthes. It is hardly necessary to emphasize the fact that the helminthes or intestinal worms do not represent a systematic group of animals, but only a biological one, and that the helminthes can only be discussed in the same sense as land and water animals are mentioned, i.e., without conveying the idea of a classification in such a grouping. It is true that formerly this was universally done, but very soon the error of such a classification was recognized. Still, until the middle of last century, the helminthes were regarded as a systematic group, although C.E. v. Baer (1827) and F.S. Leuckart (1827) strenuously opposed this view. Under the active leadership of J.A.E. Goeze, Permanent parasitism in the course of time has caused animals adopting this mode of life to undergo considerable, sometimes even striking, bodily changes, permanent ectoparasites having as yet undergone least alteration. The latter sometimes bear so unmistakably the likeness to the group to which they belong, that even a superficial knowledge of their structure and appearance often suffices for the recognition of their systematic position. For instance, though the louse, like many decidedly temporary parasites, has lost its wings—a characteristic of insects—in consequence of parasitism, yet nobody would deny its insect nature; such also occurs in other temporary parasites (Cimex, Pulex). On the other hand, the changes in a number of permanent ectoparasites (such as parasitic Crustacea) are far more considerable, and correspond with those that have occurred in permanent endoparasites. These alterations depend partly on retrogression and partly on the acquisition of new peculiarities. In the former case, the change consists in the loss of those organs which have become useless in a permanent parasitic condition of existence, such as wings in the louse, and the articulated extremities seen in the larval stage of parasitic Crustacea. The loss of these organs goes hand in hand with the cohesion of segments of the body that were originally separate, and alterations in the muscular and nervous systems. In the same manner another means of locomotion is lost—the ciliated coat—which is possessed by many permanent parasites during their larval period. To all appearances, this character is not secondary and recently acquired, but represents a primary character inherited from free-living progenitors, and still transmitted to the altered descendants, because of its use during the larval stage (e.g., the larvÆ of a great many Trematodes, the oncospheres of some Cestodes). Amongst the retrogressions, the loss of the organs of sense may be mentioned, particularly the eyes, which are still present, not only in the nearest free-living forms but also in the free-living larvÆ of true parasites. It is only quite exceptionally that the eyes are subsequently retained, as a rule they are lost. Lastly, in a great many cases the digestive system also disappears, as in parasitic Crustacea, in a few nematodes and trematodes, in all cestodes and Acanthocephala. There remain at most the rudiments of the muscles of the fore-gut, but these are adapted to entirely different uses. The new characters which permanent parasites may acquire are, first of all, the remarkably manifold CLASPING and CLINGING ORGANS, which are seldom (as in parasitic Crustacea) directly joined on to already existing structures. In those instances in which organs for the conveyance of food are retained, these likewise frequently undergo transformation, in consequence of the altered food and manner of feeding. Such alterations consist, for instance, in the transformation of a masticating mouth apparatus into the piercing and sucking organs of parasitic insects. Hermaphroditism (as in Trematodes, Cestodes, and a few Nematodes) is a further peculiarity of many permanent parasites; moreover, the association in couples that occurs, especially in trematodes, may lead to complete cohesion and, exceptionally, also to re-separation of the sexes. In many cases the females only are parasitic, while the males live a free life, or there may be in addition the so-called complementary males. Occasionally the male alone is parasitic, and in that case lives within the female of the same species, which may live free, like certain Gephyrea (Bonellia); or the female also may be parasitic, as Trichosoma crassicaudum, which lives in the bladder of the sewer rat (Mus decumanus). We have numerous proofs that demonstrate how considerably the original features of many parasites have become changed. We need only draw attention to the aforementioned LinguatulidÆ, also to many of the parasitic Crustacea belonging to various orders. In all of these a knowledge of the larval stages—in which there is no alteration, or at most only a slight degree of change—serves to determine their systematic position, i.e., the nearest conditions of relationship. The most remarkable changes are observed in those groups that contain only a few parasitic members, the majority leading a free life. A striking instance is afforded by a snail, the well-known Entoconcha mirabilis, MÜller. This mollusc consists merely of an elongated sac living in a Holothurian (Synapta digitata). It possesses none of the characteristics of either the Gastropoda or any molluscs, and in its interior there is nothing to be observed but the organs of generation and the embryos. Nevertheless, the Entoconcha is decidedly a parasitic snail, as is clearly proved by its larvÆ, but it is a snail which, in consequence of parasitism, has lost all the characteristics of molluscs in its mature condition, but still exhibits them in the early stages of development. Certain nematodes show very clearly to what devious courses parasitism may lead. The Atractonema gibbosum, the life-history of which has been described by R. Leuckart, and which lives in the larvÆ and pupÆ of a dipterous insect (Cecidomyia), exhibits, in its The researches of Lubbock, A. Schneider, and more particularly of R. Leuckart, have shown that what we call SphÆrularia bombi is not an animal but merely an organ—the vagina—of a nematode worm. This vagina at first grows, sac-like, from the body of the tiny nematode; it gradually assumes enormous dimensions (2cm. in length); it contains the sexual organs and parts of the intestine. The remaining portion of the actual animal then becomes small and shrivelled; it may be easily overlooked, being but an appendage to the vagina with its independent existence, and it finally disappears altogether. The GREAT FERTILITY of parasites is another of their peculiarities, though this may be also the case to a certain degree with some of the free-living animals, the progeny of which are likewise exposed to enormous destruction. More remarkable, however, is the fact that the young of the endoparasites only very exceptionally grow to maturity by the side of their parents. Sooner or later they leave the organ inhabited by the parents, frequently reach the open, and after a shorter or longer period of free existence seek new hosts. During their free period, moreover, a considerable growth may be attained, or metamorphosis may take place, or even multiplication. In the exceptional cases in which the young remain within the same host, they nevertheless usually quit the organ inhabited by the parents. They likewise rarely attain maturity within the host inhabited by the parents, but only, as in other cases, after having gained access to fresh hosts. These transmigrations play a very important rÔle in the natural history of the internal parasites, but they frequently conceal the cycle of development, for sometimes there are INTERMEDIATE GENERATIONS, which themselves invade intermediate hosts. Even when there are no intermediate generations, THE SYSTEM OF INTERMEDIATE HOSTS is frequently maintained by the endoparasites. According to the kind of food ingested by parasites, it has recently become usual to separate the true parasites from those animals that feed on the superfluity of the food of the host, or on products which are no longer necessary to him, and to call the latter MESSMATES or COMMENSALS. As examples, the RicinidÆ are thus designated, because, like actual lice, they dwell among the fur of mammals or the plumage of birds. They do not, however, suck blood, for which their mouth apparatus is unsuited, but subsist on useless epidermic scales. These epizoa, according to J.P. van Beneden, are, to a certain extent, useful to their hosts by removing deciduous materials which under certain circumstances might become harmful to them.1 This investigator, who has contributed so greatly to our knowledge of parasites, assigns the Ricines to the MUTUALISTS, under which term he comprises animals of various species which live in common, and confer certain benefits on one another. The mutualists are usually intimately connected in a mutually advantageous association known as “symbiosis.”2 Incidental and Pseudo Parasites.—In many cases the parasites are confined to certain hosts, and may therefore be designated as specific to such hosts. Thus, hitherto, TÆnia solium and TÆnia saginata in their adult condition have only been found in man; TÆnia crassicollis only in the cat; Brandesia (Distoma) turgida and Halipegus (Distoma) ovocaudatas only in Rana esculenta, and so forth. In many other cases, however, certain species of parasites are common to several, and sometimes many, species of hosts; Dipylidium caninum is found in the domestic cat as well as in the dog; Fasciola hepatica is found in a large number of herbivorous mammals (nineteen species), Diplodiscus (Amphistomum) subclavatus in numerous urodele and ecaudate amphibia, Holostomum variabile in about twenty-four species of birds, and so on. In these cases the hosts are almost invariably closely related, belonging, as a rule, to the same family or order, or at any rate to the same class. Trichinella spiralis, which is found in man, and in the pig, bear, rat, mouse, cat, fox, badger, polecat and marten, and is capable of being artificially cultivated in the dog, rabbit, sheep, horse, in other mammals, and even in birds, is one of the most striking exceptions. Some parasites are so strictly confined to one species of host that, even when artificially introduced into animals very closely related Under natural conditions, it is not uncommon for certain kinds of specific parasites to occur occasionally in unusual hosts. Their relationship to the latter is that of INCIDENTAL PARASITES. Thus Echinorhynchus gigas, a specific parasite of the pig, is only an incidental parasite of man; Fasciola hepatica and Dicrocoelium lanceatum are specific to numerous kinds of mammals, but may be found incidentally in man. On the other hand, Dibothriocephalus latus, a specific parasite of man, may occasionally take up its abode in the dog, cat and fox. As a rule, all those parasites of man that are only rarely met with, notwithstanding that human beings are constantly being observed and examined by medical men, are termed INCIDENTAL PARASITES OF MAN. In many cases we are acquainted with the normal or specific host of these parasites. Thus we know the specific host of Balantidium coli, Eimeria stiedÆ, Fasciola hepatica, Dipylidium caninum, etc.; in others the host is as yet unknown. In the latter case the question partly relates to such forms as have been so deficiently described that their recognition is impossible, partly to parasites of man in various regions of the earth, the Helminthes and parasites of which are totally unknown or only slightly known, or finally to early developmental stages that are difficult to identify. Animals that usually live free, and exceptionally become parasitic, may likewise be called incidental parasites. In this category are included a few AnguillulidÆ that have been observed in man; also Leptodera appendiculata, which usually lives free, but may occasionally become parasitic in black slugs (Arion empiricorum): when parasitic it attains a larger size, and produces far more eggs than when living a free life. In order to avoid errors, the term “incidental parasites” should be confined to true parasites which, besides living in their normal host, may also live in other hosts. Leuckart speaks of FACULTATIVE PARASITISM in such forms as Leptodera. L. Oerley3 succeeded in artificially causing Leptodera (Rhabditis) pellio to assume facultative parasitism by introducing these Recently the incidental parasites of man have also been called “Pseudo-parasites” or “Pseudo-helminthes.” Formerly, however, these terms were applied not only to living organisms that do not and cannot live parasitically, and that only exceptionally and incidentally get into man, but also to any foreign bodies, portions of animals and plants, or even pathological formations that left the human system through the natural channels, and the true nature of which was misunderstood. Frequently these bodies were described as living or dead parasites and labelled with scientific names, as if they were true parasites. A study of these errors, which formerly occurred very frequently, would be as interesting as it would be instructive. It is better not to use the expression pseudo-parasites for incidental parasites, but to keep to the original meaning, for it is not at all certain that pseudo-parasites are not described, even nowadays. The Influence of Parasites on the Host.—In a great many cases, we are not in a position to state anything regarding any marked influence exercised by the parasite on the organism, and on the conditions of life, of the host. Most animals and many persons exhibit few signs of such influence, an exception being infestation with helminthes and certain other parasites which produce eosinophilia in the blood. As a general rule, the parasite, which is always smaller and weaker than its host, does not attempt to endanger the life of the latter, as simultaneously its own existence would be threatened. The parasite, of course, robs its host, but usually in a scanty and sparing manner, and the injuries it inflicts can hardly be taken into account. There are, however, numerous cases4 in which the situation of the parasites or the nature of their food, added to their number and movements, may cause more or less injury, and even threaten the life of the host. It stands to reason that a Cysticercus cellulosÆ situated in the skin is of but slight importance, whereas one that has penetrated the eye or the brain must give rise to serious disorders. A cuticular or intestinal parasite is, as a rule, less harmful than a blood parasite. A helminth, such as an Ascaris lumbricoides or a tapeworm, that feeds on the residues of foodstuffs within the intestine, will hardly Generally, the disorders caused by loss of chyle are insignificant when compared with those induced by the GROWTH and agglomeration of the helminthes. The latter may cause chiefly obstructions of small vessels or symptoms of pressure in affected or contiguous organs, with all those complications which may arise secondarily, or they may even lead to the complete obliteration of the organ invaded. Of course the symptoms will vary according to the nature of the organ attacked. In consequence also of the MOVEMENTS of the parasites, disorders are set up that may tend to serious pathological changes of the affected organs. The collective migrations, undertaken chiefly by the embryos of certain parasites (as in trichinosis, acute cestode tuberculosis), are still more harmful, as are also the unusual migrations of other parasites, which, incidentally, may lead to the formation of so-called worm abscesses or to abnormal communications (fistulÆ) between organs that are contiguous but possess no direct connection. Recently, several authors have called attention to the fact that the helminthes produce substances that are TOXIC to their host; and the effects of such poisons explain the pathology of helminthiasis far more satisfactorily than the theory of reflex action. In a number of cases these toxic materials (leucomaines) have been isolated and their effects on living organisms demonstrated by actual experiments. It also appears that the absorption of materials formed by the decomposition of dead helminthes may likewise cause toxic effects. However, our knowledge of these conditions is as yet in its initial stage.5 Nearly all the symptoms caused directly or indirectly by parasites are of such a nature that the presence of the parasites cannot be diagnosed with any certainty, or only very rarely. The most that can be done is to deduce the presence of parasites by the exclusion of other causes. Fortunately, however, there are sufficient means Origin of Parasites.6—In former times, when the only correct views that existed related to the origin of the higher animals, the mode of multiplication of parasites as well as of other lowly animals was ascribed to SPONTANEOUS GENERATION (generatio Æquivoca), and this opinion prevailed throughout the middle ages. The writers on natural science merely devoted their time to the interpretation of the views of the old authors, and perpetuated the opinions of the ancients on questions, which, even in those days, could have been correctly explained merely by observation. It was only when observations were again recommenced, and the microscope was invented, that the idea of spontaneous generation became limited. Not only did the microscope reveal the organs of generation or their products (eggs) in numerous animals, but Redi succeeded in proving that the so-called Helcophagi (flesh maggots) are only the progeny of flies, and never appear in the flesh of slaughtered animals when fully developed flies are prevented from approaching and depositing their eggs on it. Swammerdam likewise knew that the “worms” living in the caterpillars of butterflies were the larvÆ of other insects (ichneumon flies) which had laid their eggs in their bodies; he also discovered the ova of lice. The two authors mentioned were, however, unwilling to see that the experience they had gained regarding insects applied to the helminthes. Leeuwenhoek also vehemently opposed the theory of a spontaneous generation, maintaining that, on a basis of common-sense, eggs, or at all events germs, must exist, even though they could not be seen. The use of the microscope also revealed a large number of very small organisms in the water and moist soil, some of which undoubtedly resembled helminthes. Considering the wide dissemination of these minute organisms, it was natural to conjecture that after their almost unavoidable introduction into the human system they should grow into helminthes (Boerhave, Hoffmann). LinnÆus went even further, for he traced the descent of the liver-fluke of sheep from The more minute comparison between the supposed free-living stages of the helminthes and their adult forms, and the impossibility of finding corresponding free forms for the ever-increasing number of parasitic species, revealed the improbability of LinnÆus’ statements (O. Fr. MÜller). It was the latter author also who recognized the origin of the tapeworms (Schistocephalus, Ligula) found free in the water. They originate from fishes which they quit spontaneously. However, in spite of the fact that van Doeveren and Pallas correctly recognized the significance of the eggs in the transmission of intestinal worms, these statements remained disregarded, as did Abildgaard’s observation, experimentally confirmed, that the (immature) cestodes from the abdominal cavity of sticklebacks became mature in the intestines of aquatic birds. Moreover, at the end of the eighteenth and the commencement of the nineteenth centuries, after helminthology had been raised to a special branch of study by the successful results of the investigations of numerous authors (Goeze, Bloch, Pallas, MÜller, Batsch, Rudolphi, Bremser), many of whom experienced a “divine joy” in searching the intestines of animals for helminthes, some authors reverted to generatio Æquivoca, without, however, entirely denying the existence of organs of generation and eggs. The fact that a few nematodes bore living progeny—a fact of which Goeze was already aware—had no influence on the erroneous opinion, as in such cases it was considered that the young continued to develop beside the old forms. There were also These views, firmly rooted and supported by such eminent authorities as Rudolphi and Bremser, could not easily be overthrown. First, a change took place in the knowledge of the trematodes. In 1773, O. Fr. MÜller discovered CercariÆ living free in water. He regarded them as independent creatures and gave them the name that is still used at the present time. Nitzsch, who also minutely studied these organisms and who recognized the resemblance of the anterior part of their bodies to a Fasciola, did not, however, arrive at a correct conclusion. He regarded the combination rather as that of a Fasciola with a Vibrio, for which he mistook the characteristic tail of the cercaria. He also noticed the encystment (transformation into the “pupa”) on foreign bodies of many species of these animals, but was of opinion that this process signified only the termination of life. Considerable attention was attracted to the matter when Bojanus first published a paper entitled “A Short Note on Cercaria and their Place of Origin.” He pointed out that the cercariÆ creep out of the “royal yellow worms,” which occur in freshwater snails (LimnÆa, Paludina), and are probably generated in these worms. Oken, in whose journal, Isis (1818, p.729), Bojanus published his discovery, remarks in an annotation, “One might lay a wager that these CercariÆ are the embryos of Distomes.” Soon after (1827), C.E. v. Baer was able to confirm Bojanus’ hypothesis that the cercariÆ as a “heterogeneous brood” originated from spores in parasitic tubes in snails (germinating tubes). Moreover, Mehlis (Isis, 1831, p. 190) not only discovered the opercula of the ova of Distoma, but likewise saw the infusorian-like embryo emerge from the eggs of Typhlocoelum (Monostomum) flavum and CathÆmasia (Distoma) hians. A few years later (1835) v. Siebold observed the embryos (miracidia) of the Cyclocoelum (Monostomum) mutabile, and discovered in their interior a cylindrical body that behaved like an independent being (“necessary parasite”), and was so similar in appearance to the “royal yellow worms” (Bojanus) that Siebold considered the origin of the latter from the embryos of trematodes as, at all events, possible. Meanwhile, v. Nordmann of Helsingfors had in 1832 seen the miracidia of flukes provided with eyes swimming in water; v. Siebold (1835) had observed J.I. Steenstrup (1842) was, however, the first to furnish explanations for the numerous isolated and uncomprehended discoveries. Commencing with the remarkable development of the Coelenterata, he established the fact that the Helminthes, especially the endoparasitic trematodes, multiply by means of alternating and differently formed generations. Just as the polyp originating from the egg of a medusa represents a generation of medusÆ, so does the germinal tube (“royal yellow worm”) originating from the ciliated embryo of a Distoma, etc., represent the cercaria. These were consequently regarded as the progeny of trematodes, and Steenstrup, guided by his observations, conjectured that the cercaria, whose entrance into the snails he had observed accompanied by the simultaneous loss of the propelling tail, finally penetrated into other animals, in which they became flukes. Part of this hypothetical cycle of development was erroneous, and in other particulars positive observation was lacking, but the path pursued was in the right direction. Immediately after the appearance of Steenstrup’s celebrated work, v. Siebold expressed his opinion that the encapsuled flukes certainly had to travel, i.e., to be transmitted with their bearers into other hosts, before becoming mature. This view was experimentally confirmed by de Filippi, La Valette St. George (1855), as well as by Pagenstecher (1857), while the metamorphosis of the ciliated embryo of Distoma into a germinal tube was first seen by G. Wagener (1857) in Gorgodera (Distoma) cygnoides of frogs. All that we have subsequently learned from the works of numerous investigators about the development of endoparasitic trematodes has certainly increased our knowledge in various directions, and, apart from the deviating development of the HolostomidÆ has, as a whole, confirmed the briefly sketched cycle of development. Steenstrup’s work on the cestodes did not attract the same attention as his work on trematodes. Steenstrup always insisted on the “nurse” nature of the cysticerci and other bladder-worms. Abildgaard (1790), as well as Creplin (1829 and 1839), had already furnished the information that certain sexless cestodes (Schistocephalus and It was correctly believed that the ova or oncospheres penetrate into certain intermediate hosts, in which they develop into unsegmented larvÆ. Here they remain until, with their host, they are swallowed by some predacious animal. They then reach the intestine, being freed from the surrounding membranes through the process of digestion, and settle themselves there to form the adult chain of proglottides. Though some few scientists, such as P.J. van Beneden and Em. Blanchard, deduced from these observations that the bladder-worms (Cysticerci), which had hitherto been regarded as a separate class of helminthes, were only larval TÆniÆ, this correct view was not at first universally accepted. The foundation was too slight, and van Beneden was of opinion that the Cysticerci were not necessary, but only appeared incidentally. v. Siebold was a strenuous opponent to this theory, notwithstanding his experiences on the change of hosts of the Tetrarhynchus. Together with Dujardin (1850) he conjectured that the TÆniÆ underwent a deviating cycle of development. He was of opinion that the six-hooked oncospheres left the intestine, in which the older generation lived, and were scattered about with the fÆces, and finally re-entered per os (i.e., with water and food) a host similar to the one they had left, in the intestine of which they were directly transformed into tapeworms. A change of host such as occurred in other cestodes was not supposed to take place (the history of the cestodes was at this time not entirely established). As the oncospheres of the TÆnia are enveloped in one calcareous or several softer coverings which they cannot leave actively, and as, in consequence of this condition, innumerable oncospheres cannot penetrate into an animal, and others cannot reach the proper animal, v. Siebold conceded, at least for the latter, the possibility of a further development. But this was only supposed to occur because they had either invaded wrong hosts, or, having reached the right hosts, had penetrated organs unsuitable to their development, and had thus gone astray in their travels, and had become hydropically degenerated tÆniÆ. This was v. Siebold’s explanation of bladder-worms. Naturally, v. Siebold himself conjectured that a recovery of the diseased tapeworm might occur, in a few exceptional cases, after transmission into the correct host, as, for instance, in the Cysticercus fasciolaris of mice, the host of which is the domestic cat, and in which there is a seemingly normally Guided by correct views, F. KÜchenmeister undertook in Zittau the task of confirming the metamorphosis of Cysticercus pisiformis of hares and rabbits, into tapeworms in the intestine of the dog by means of feeding experiments. The first reports on the subject, published in 1851, were not likely to meet with universal approval, because KÜchenmeister first diagnosed the actual tapeworm he had been rearing as TÆnia crassiceps, afterwards as TÆnia serrata, and finally as TÆnia pisiformis n. sp. However, in any case, KÜchenmeister, by means of the reintroduction of experimental investigation, rendered a great service to helminthology. The publication of KÜchenmeister’s works induced v. Siebold to undertake similar experiments (1852 and 1853), which were partly published by his pupil Lewald in 1852. But the positive results obtained hardly changed Siebold’s opinion, for although he no longer considered the bladder-worms as hydropically degenerated tapeworms, he still regarded them as tÆniÆ that had strayed. The change of opinion was partly due to an important work of the Prague zoologist, v. Stein (1853). He was able to examine the development of a small bladder-worm in the larvÆ of the well-known meal-worm (Tenebrio molitor) and to demonstrate that, as Goeze had already proved in the case of Cysticercus fasciolaris of mice, first the caudal vesicle is formed and then the scolex, whereas Siebold believed that in bladder-worms the posterior end of the scolex was formed first, and that this posterior end underwent a secondary hydropic degeneration. In opposition to v. Siebold, KÜchenmeister successfully proved the necessity of the bladder-worm stage by rearing tapeworms in dogs from the Cysticercus tenuicollis of domestic mammals and from the Coenurus cerebralis of sheep. He, and simultaneously several other investigators independently, succeeded, with material provided by KÜchenmeister, in rearing the Coenurus cerebralis in sheep from the oncospheres of the TÆnia coenurus of the dog (1854). R. Leuckart obtained similar results in mice by feeding them with the mature proglottides of the TÆnia crassicollis of cats (1854). KÜchenmeister also repeatedly reared the TÆnia solium of man from the Cysticercus cellulosÆ of pigs (1855), and from the embryos of this parasite P.J. van Beneden succeeded in obtaining the same Cysticercus in the pig (1854). As KÜchenmeister distinguished the TÆnia mediocanellata, known to Goeze as TÆnia saginata, amongst the large tÆniÆ of man (1851), so it was not long before R. Leuckart (1862) succeeded in rearing the cysticercus of the hookless tapeworm in the ox. It is particularly to this last-named investigator that helminthology is indebted more than to any other author. He In view of all the researches that were made, and which are too numerous to mention individually, the idea that bladder-worms are abnormal or only incidental forms had to be abandoned. Everything pointed to the fact that in all cestodes the development is divided between two kinds of animals; in one—the host, the adult tapeworm is found; while in the other, the intermediate host, we find some form or other of an intermediate stage (cysticercus in the broadest sense). The practical application of this knowledge is self-evident. If no infected pork or beef is ingested, no tapeworm can be acquired, and also the rearing of cysticerci in the human body is prevented by avoiding the introduction of the eggs of tapeworms. Though these results were definitely proved by numerous researches, yet they have been repeatedly challenged, notably by J. Knoch (1862) in Petrograd, who, on the basis of experiments, sought to confirm a direct development without an intermediate host and ciliated stage, at all events as regards Dibothriocephalus latus. However, the repeated communications of this author met with but little favour from competent persons, partly because the experiments were conducted very carelessly, and partly because their repetition on dog and man (R. Leuckart) had no results (1863). It was only in 1883 that Braun was able to prove that the developmental cycle of Dibothriocephalus latus is similar to that of other Cestodes. The results obtained in other places by Parona, Grassi, Ijima and Zschokke render any discussion of KÜchenmeister’s conclusions unnecessary.7 Long after Knoch, a French author, P. MÉgnin, also pleaded for the direct development of some cestodes, and especially some tÆniÆ. He (1879) also sought to prove a genetic connection between the hookless and armed tapeworms of mammals, but the arguments he adduced, so far as they rest on observations, can be easily refuted or attributed to misinterpretation. Only one of these arguments is correct, namely, that the number of the species of tÆniÆ with which we are acquainted is far larger than that of the corresponding cystic forms; but this disparity alone cannot be taken as a proof of direct development. It can only be said that our knowledge in this respect is deficient. As a matter of fact, we have during recent years become acquainted with a large number of cystic forms, hitherto unknown, belonging to tÆniÆ which have long been familiar. It must also be borne in mind that no man in his lifetime can complete an examination for bladder-worms of the large number of insects, for instance, which Naturally it does not follow that direct development in the cestodes is altogether lacking. The researches of Grassi (1889) have furnished an example in Hymenolepis (TÆnia) murina, which shows that development may sometimes take place without an intermediate host, notwithstanding the retention of the cystic stage. It was found that the oncospheres of this species, introduced into rats of a certain age, after a time grow into tapeworms without leaving the intestine, but not directly, for they bore into the intestinal wall, where they pass the cystic stage, the cysts afterwards falling into the intestinal lumen, where they develop into tapeworms. The recent experiments of Nicoll (1911) show that the larval stages of Hymenolepis murina also occur in the rat-flea, Ceratophyllus fasciatus. Important observations were soon made on the remaining groups of helminthes. The discussion on the origin of parasites soon became confined to the helminthes. Amongst the Nematoda, it had long been known that encapsuled forms existed that had at first been regarded as independent species, but very soon they were pronounced to be immature forms, in consequence of their lack of sexual organs. Though Dujardin and also v. Siebold regarded them as “strayed” animals, v. Stein (1853) very promptly demonstrated that the progeny of the nematodes were destined to travel by discovering a perforating organ in the larval nematodes of the mealworm. This was first experimentally confirmed (1860) by R. Leuckart, R. Virchow and Zenker, all of whom succeeded not only in bringing to maturity the muscle TrichinÆ (known since 1830) in the intestine of the animals experimented upon, but were likewise able to follow the migrations of the progeny. Of course, the encapsulating brood remained in the same organism, and in this respect deviated from the broods of other helminthes which escape into the outer world and find their way into other animals, but the encapsuled nematodes could no longer be regarded as the result of straying. Subsequently, R. Leuckart worked out, more or less completely, the history of the development of numerous nematodes, or pointed out the way in which further investigations should be made. It has been found that in nematodes far more frequently than in other helminthes, the typical course of development is subject partly to curtailment and partly to complications, which sometimes considerably increase the difficulties of investigation and have hitherto prevented the attainment of a definite conclusion, though the way to it is now clear. In a similar manner the works of R. Leuckart have cleared up the development of the Acanthocephala and Linguatulida. Of The deductions to be drawn are as follows: That the helminthes like the ectoparasites multiply by sexual processes, that the entire course of development of the helminthes is rarely or never gone through in the same host as is the case with several ectoparasites, that the progeny at an earlier or later stage of development, as eggs, embryos, or larvÆ, quit the host inhabited by the older generation, and almost always attain the outer world: only in Trichinella does the development take place directly in the definite host. Where the eggs have not yet developed they go through the embryonic evolution in the outer world. The young larvÆ are transmitted, either still enclosed within the egg or embryonic covering, to the intermediate host or more rarely they are transferred straight to the final host. In other cases they may hatch out from their envelopes, and after a longer or shorter period of free life, during which they may partake of food and grow, they, as before, penetrate, usually in an active way, into an intermediate host, or at once invade the final host. Exceptionally (e.g., Rhabdonema), during the free life there may be a propagation of the parasitic generation, and in this case only the succeeding generation again becomes parasitic, and then at once reaches its final host. The young forms which have invaded the final host become mature in the latter, or after a longer or shorter period of parasitism again wander forth (as the ŒstridÆ, IchneumonidÆ, etc.), and reach the adult stage in the outer world. The young stages, during which the parasites undergo metamorphoses or are even capable of producing one or several intermediate generations, are passed in the intermediate hosts until, as a rule, they are passively carried into the final host and there complete their cycle of development by the formation of the organs of generation. This mode of development, the spending of life in two different kinds of animals (intermediate and final host), is typical of the helminthes. This is manifested in the Acanthocephala, the Cestoda, the majority of the endoparasitic Trematoda, a number of the Nematoda, and the LinguatulidÆ. There are now and then exceptions, however, in which, for instance, the host and intermediate host change order (Trichinella, Hymenolepis murina). Parasites are hardly ever inherited amongst animals.8 According to a few statements, however, Trichinella and Coenurus are supposed to be transmissible from the infected mother to the foetus. Otherwise most animals acquire their parasites, especially the Entozoa, from without, the parasites penetrating either actively, as in animals living in the water, or passively with food and drink. A particular predisposition to worms is not more likely than a spontaneous origin of parasites. Derivation of Parasites.—Doubt now no longer exists as to the derivation of the temporary and of many of the stationary ectoparasites from free-living forms. This conclusion is founded on the circumstance that not only are there numerous intermediate degrees in the manner of living and feeding between predacious and parasitic animals, but that there is more or less uniformity in their structure. The differences that exist are easily explained as consequences of altered conditions of life. The case is more difficult in regard to groups that are exclusively parasitic (Cestoda, Trematoda, Acanthocephala, LinguatulidÆ, and Sporozoa), or groups that are chiefly parasitic (Nematoda), because in these cases the gulf that divides these forms from free-living animals is wider. It is true that we know that the nearest relatives of the LinguatulidÆ are found amongst the Arachnoidea, and indeed in the Acarina; that, moreover, the structure and development of the Sporozoa refers them to the Protozoa, and allows some of them to be regarded as the descendants of the lowest Rhizopoda. We know that the Trematoda, and through these the Cestoda, are closely related to the Turbellaria, from which they may be traced. The Nematoda, and still more the Acanthocephala, stand apart. This is less evident, however, in the Nematoda, for there are numerous free-living members of these from which it is possible that the parasitic species may be descended. Indeed, this seems more than probable if such examples as Leptodera, Rhabdonema and Strongyloides are taken into consideration, as well as the conditions of life of free-living nematodes. These mostly, if not exclusively, spend their lives in places where decomposing organic substances are present in quantities; some species attain maturity only in such localities, and there propagate very rapidly. Should the favourable conditions for feeding be changed, the animals seek out other localities, or they remain in the larval form for some time until more favourable conditions set in. It is comprehensible that such forms are very likely to adopt a parasitic manner of life which at first is facultative (Leptodera, Anguillula), but may be regarded as the transition Though it is possible thus to connect the parasitic with the free-living nematodes, by taking their manner of life into account, this matter presents greater difficulties in regard to other helminthes. It is true that the segmented Cestoda may be connected with and traced from the less known and interesting single-jointed Cestoda (Amphilina, Archigetes, CaryophyllÆus, Gyrocotyle). Trematodes are all parasites, with the exception of one group, TemnocephalidÆ, several genera and species of which live on the surface of the bodies of Crustacea and turtles of tropical and sub-tropical freshwaters. TemnocephalidÆ are, nevertheless, predacious. They feed on Infusoria, the larvÆ of small insects and Crustacea. So far as is known they do not nourish themselves on part of the host. They belong to the group of commensals, or more correctly, to that of the SPACE PARASITES, which simply dwell with their host and do not even take a portion of the superfluity of its food. However, space parasitism may still be regarded as the first stage of commensalism, which is again to be regarded as a sort of transition to true parasitism. It is possible that parasitism came about in this way in the trematodes, in which connection we must first consider the turbellaria-like ancestors of the trematodes. Much can be said in favour of such a genetic relationship between turbellaria and trematodes, and hardly anything against it. It should also be remembered that amongst the few parasitic turbellaria there are some that possess clinging discs or suctorial pores, and these are only differentiated from ectoparasitic trematodes by the possession of a ciliated integument, which is found only in the larval stages of the latter. The Acanthocephala occupy an isolated position. Most authors certainly regard them as related to the nematodes; in any case, the connection is not a close one, and the far-reaching alterations which must have occurred prevent a clear view. Perhaps the free original forms of Acanthocephala are no longer in existence, but that such must have existed is a foregone conclusion. An explanation of the CHANGE OF HOST so frequent in parasites is more difficult than that of their descent. R. Leuckart is of opinion that the present intermediate hosts, which belong principally to the lower animals, were the original hosts of the parasites, and fostered Leuckart therefore regards the change of hosts as secondary, so does Sabatier. The latter, however, adduces other reasons for this (lack of clinging organs and the necessity to develop them in an intermediary stage); but in this connection he only considers the Cestoda. In opposition to Leuckart, R. Moniez, however, is convinced that the migrations of the helminthes, as well as the system of intermediate hosts, represent the original order of things. Moniez traces all Entozoa from saprophytes, but only a few of these were able to settle directly in the intestine and there continue their development. These are forms that at the present day still lack an intermediate host, such as Trichocephalus, Ascaris, and Oxyuris. In most other cases the embryos, however, consisted of such saprophytes as were, in other respects, suitable to become parasites, but were incapable of resisting the mechanical and chemical influences of the intestinal contents. They were therefore obliged to leave the intestine at once, and accomplished this by penetrating the intestinal walls and burrowing in the tissues of their carriers. In this position, assisted by the favourable conditions of nutrition, they could attain a relatively high degree of development. Mechanical reasons prevented a return to the intestines, where the eggs could be deposited. Most of them doubtless died off as parasites, as also their young stages do at present when they penetrate wrong hosts. Some of them, nevertheless, passively reached the intestine of beasts of prey. Many were destroyed in the process of mastication; for a small part, however, there was the chance of reaching the intestine of a beast This is not the place to express an opinion either for or against the various hypotheses advanced, but the existence of these diametrically opposed views alone will show the great difficulty of the question. Independently, however, it appears more natural to come to the conclusion that parasitism, as well as change of hosts, were gradual transitions. As a conclusion to this introductory chapter, a list of some of the most important works on the parasitology of man and animals is appended. LITERATURE. Goeze, J.A.E. Versuch einer Naturgeschichte der EingeweidewÜrmer thierischer KÖrper. Blankenburg, 1782. 4to, 471 pp., with 44 plates. Zeder, J.G.H. Erster Nachtrag zur Naturgeschichte der EingeweidewÜrmer. von J.A.E. Goeze. Leipzig, 1800. 4to, with 6 tables. Rudolphi, C.A. Entozoorum sive vermium intestinalium historia naturalis. I, Amstelod., 1808; ii, 1809. 8vo, with 18 plates. Rudolphi, C.A. Entozoorum synopsis. Berol., 1819. 8vo, with 3 plates. Bremser, J.G. Ueber lebende WÜrmer im lebenden Menschen. Wien, 1819. 8vo, with 4 plates. Bremser, J.G. Icones helminthum, systema Rudolphii entozoologicum illustrantes. Viennae, 1824. Fol. (Paris, 1837). Dujardin, F. Histoire naturelle des helminthes ou vers intestinaux. Paris, 1845. 8vo, with 12 plates. Diesing, C.M. Systema helminthum. 2 vols.Vindobonnae, 1850, 1851. 8vo. Supplements by the same author: Revision der Myzhelminthen (Report of the Session of the Imp. Acad. of Science. Wien, xxxii, 1858); with addendum (ibid., xxxv, 1859); Revision der Cephalocotyleen (ibid., xlix, 1864, and xlviii, 1864); Revision der Nematoden (ibid., xlii, 1861); Supplements (ibid., xliii, 1862). Beneden, P.J. VAN. MÉmoire sur les Vers intestinaux. Paris, 1858. 4to, with 12 plates. KÜchenmeister, F. Die in und an dem KÖrper des lebenden Menschen vorkommenden Parasiten. Leipzig, 1855. 8vo, with 14 plates. Leuckart, R. Die menschlichen Parasiten und die von ihnen herrÜhrenden Krankheiten. I, Leipzig, 1863; II, Leipzig, 1876. 8vo. Cobbold, T. Sp. Entozoa; an Introduction to the Study of Helminthology. London, 1864. 8vo. Supplement, London, 1869. Davaine, C. TraitÉ des entozoaires et des maladies vermineuses de l’homme et des animaux domestiques. 2nd edit. Paris, 1877. 8vo. Linstow, O.V. Compendium der Helminthologie, ein Verzeichniss der bekannten Helminthen, die frei oder in thierischen KÖrpern leben, geordnet nach ihren Wohnthieren, unter Angabe der Organe, in denen sie gefunden sind, und mit BeifÜgung der Litteraturquellen. Hanov., 1878. 8vo. Supplement, including the years 1878–1888, Hanov., 1888. Cobbold, T. Sp. Parasites; a Treatise on the Entozoa of Man and Animals, including some Account of the Entozoa. London, 1879. 8vo. Leuckart, R. Die Parasiten des Menschen und die von ihnen herrÜhrenden Krankheiten. 2nd edit. Leipzig, 1879–1886. The Protozoa, Cestodes, Trematodes and Hirudinea have hitherto appeared (continued by Brandes). BÜtschli, O. Protozoa in Bronn’s Klass. u. Ordn. d. Thierreichs. Vol.i, Leipzig, 1880–1889. 8vo, with 79 plates. Braun, M. Trematodes in Bronn’s Klass. u. Ordn. d. Thierreichs. Vol.iv, 1, Leipzig, 1879–1893. 8vo, with 33 tables. (The first thirteen sheets, comprising the history of the worms up to 1830, were compiled by H. Pagenstecher.) ZÜrn, F.A. Die thierischen Parasiten auf und in dem KÖrper unserer HaussÄugethiere, sowie die durch erstere veranlassten Krankheiten, deren Behandlung und VerhÜtung. 2nd edit. Weimar, 1882. 8vo, with 4 plates. Cobbold, T. Sp. Human Parasites; a Manual of Reference to all the Known Species of Entozoa and Ectozoa. London, 1882. 8vo. KÜchenmeister, F., and F.A. ZÜrn. Die Parasiten des Menschen. 2nd edit. Leipzig, 1888., 8vo, with 15 plates. Blanchard, R. TraitÉ de zoologie mÉdicale. I, Paris, 1889; II, 1890. 8vo. Neumann, L.G. TraitÉ des maladies parasitaires non microbiennes des animaux domestiques. 2nd edit. Paris, 1892. 8vo. English edit., translated by G. Fleming. 2nd edit., revised by J. Macqueen. 1905. London: BailliÈre, Tindall and Cox. Looss, A. Schmarotzerthum in der Thierwelt. Leipzig, 1892. 8vo. Railliet, A. TraitÉ de zoologie mÉdicale et agricole. 2nd edit. I, Paris, 1895. 8vo. Parona, C. L’elmintologia italiana da’ suoi primi tempi all’ anno 1890. Genova, 1894. 8vo. Braun, M. Cestoda in Bronn’s Klass. u. Ordn. d. Thierreichs. Vol.iv, 2, Leipzig, 1894–1900. 8vo, with 24 plates. Mosler, F., and E. Peiper. Thier Parasit. (Spec. Path. u. Ther. v. H. Nothnagel. Vol.vi.) Wien, 1894. 8vo, with 124 illustrations. Laveran, A., et R. Blanchard. Les hÉmatozoaires de l’homme et des anim. Paris, 1895. 12mo, with 30 figs. Sluiter, C.R. De dierl. paras. v. d. mensch en van onze huisdier. Haag, 1895. 8vo. Blanchard, R. Malad. parasit., paras. animaux, paras. vÉgÉt. À l’exclus. des bacter. (TraitÉ de pathol. gÉn. de Ch. Bouchard, vol.ii.) Paris, 1895. 8vo, with 70 figs. Huber, J. Ch. Bibliographie der klin. Helminthol. MÜnchen, 1895. 8vo. With Supplement, 1898, and continued as Bibl. d. klin. Entomol. MÜnchen, 1899–1900. Moniez, R. TraitÉ de parasitol. anim. et veget. appl. À la mÉdecine. Paris, 1896. 8vo, with 116 figs. Weichselbaum. Parasitologie (Weil’s Handb. d. Hyg.). Jena, 1898. 8vo, with 78 illustrations. Kraemer, A. Die thierischen Schmarotzer des Auges (GrÄfe and SÄmische’s Handb. d. ges Augenheilk.). Leipzig, 1899. 8vo, with 16 illustrations. Cholodkowsky, N.A. Icones helm. hominis. St. Petersburg, 1898–99. Fol. (atlas with 15 plates). Perroncito, E. I parassiti dell’ uomo e degli animali utili e le piÙ comuni malattie da essi prodotti. II_{a} ed. Milano 1902. 8o. con 276 fig. e 25 tav. Stiles, Ch. W. and A. Hassall. Index Catalogue of Medicine and Veterinary Zoology. Washington, 1902 (U.S. Dept. of Agric., Bur. of Anim. Ind., Bull. No. 39). Neveu-Lemaire, M. PrÉcis de parasitologie humaine, parasites vÉgÉtaux et animaux. 4e Édit. Paris, 1911. Hofer, B. Handbuch der Fischkrankheiten. MÜnchen, 1904. 8o. 18 Taf. 222 Abb. Guiart, J., and L. Grimbert. PrÉcis de Diagnostic chimique, microscopique et parasitologique. Paris, 1906. With 500 figs. Ostertag, R. Handbuch der Fleischbeschau. V. Aufl. mit 265 Abb. Stuttgart, 1904. Stiles, Ch. W. The International Code of Zoological Nomenclature as applied to Medicine (Hygienic Lab., Bull. No. 24, Washington, 1905). Stiles, C.W., and Hassall, A. Trematoda and Trematode Diseases. (Index Catalogue of Med. and Vet. Zoology.) Hygienic Lab., Bull. No. 37, Washington, 1908. Stiles, C.W., and Hassall, A. Cestoda and Cestodaria. Hygienic Lab., Bull. No. 85, Washington, 1912. Laloy, L. Parasitisme et mutualisme dans la nature. Paris, 1906. 8vo, 284 pp., 82 figs. Theobald, F.V. A Monograph of the CulicidÆ of the World. 5 vols. and plates. 1901–1910. London: Brit. Museum, Nat. Hist. James, S.P., and Liston, W.G. The Anopheline Mosquitoes of India. 2nd edit. 1911. Calcutta: Thacker, Spink and Co. Howard, L.O., Dyar, H.G., and Knab, F. The Mosquitoes of North and Central America and the West Indies. 2 vols. 1912. Washington: Carnegie Institution. Austen, E.E. African Blood-sucking Flies. 1909. London: Brit. Museum, Nat. History. Austen, E.E. A Handbook of Tsetse-flies. 1911. London: Brit. Museum, Nat. History. Castellani, A., and Chalmers, A.J. Manual of Tropical Medicine. 2nd edit. 1,747 pp.1913. London: BailliÈre, Tindall and Cox. Kolle and Wassermann. Handbuch der pathogenen mikroorganismen. Jena: Gustav Fischer. Minchin, E.A. An Introduction to the Study of the Protozoa. 1912. London: Arnold. Laveran, A., et Mesnil, F. Trypanosomes et Trypanosomiases. 2nd edit. 1912. Paris: Masson and Co. Doflein, F. Lehrbuch der Protozoenkunde. 3rd edit. 1911. Jena: Gustav Fischer. Nuttall, G.H.F., Warburton, C., Cooper, W.F., and Robinson, L.E. Ticks—a Monograph of the Ixodoidea. Pt. I (1908). Pt. II. (1911). University Press, Cambridge, England. Brumpt, E. PrÉcis de Parasitologie. 2nd edit. 1913. Paris: Masson and Co. Patton, W.S., and Cragg, F.W. A Text-book of Medical Entomology. 1913. Christian Literature Society of India: London, Madras, and Calcutta. JOURNALS. For current researches the following, among others, should be consulted:— Annals of Tropical Medicine and Parasitology, Liverpool. Annales de l’Institut Pasteur, Paris. Archives de Parasitologie, Paris. Archives de Zoologie ExpÉrimentale et GÉnÉrale, Paris. Archiv fÜr Protistenkunde, Jena. Archiv fÜr Schiffs- und Tropen-Hygiene, Leipzig. Bulletin of Entomological Research, London. Bulletin de l’Institut Pasteur, Paris. Bulletin de la SociÉtÉ de Pathologie Exotique, Paris. Bulletins of the Bureau of Animal Industry, Washington. Centralblatt fÜr Bakteriologie und Parasitenkunde, Jena. Compt. Rend. Acad. Sci., Paris. Compt. Rend. Soc. Biol., Paris. Indian Journal of Medical Research, Calcutta. Journal of Experimental Medicine, New York. Journal of Medical Research, Boston. Memorias do Instituto Oswaldo Cruz, Rio de Janeiro. Parasitology, Cambridge. Proceedings of the Royal Society, London. Quarterly Journal of Microscopical Science, London. Review of Applied Entomology, London. Tropical Diseases Bulletin (London: Tropical Diseases Bureau). Zeitschrift fÜr Infektionskrankheiten, Berlin. |